Computational Biology

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Improving Assessment of Drug Safety Through Proteomics: Early Detection and Mechanistic Characterization of the Unforeseen Harmful Effects of Torcetrapib
Stephen A. Williams, Ashwin C. Murthy, Robert K. DeLisle, Craig Hyde, Anders Malarstig, Rachel Ostroff, Sophie J. Weiss, Mark R. Segal and Peter Ganz

Circulation. 2017;CIRCULATIONAHA.117.028213, originally published October 3, 2017
https://doi.org/10.1161/CIRCULATIONAHA.117.028213

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Machine Learning in Medicine
Rahul C. Deo

Circulation. 2015;132:1920-1930, originally published November 16, 2015
https://doi.org/10.1161/CIRCULATIONAHA.115.001593

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NADPH Oxidase 4 Induces Cardiac Fibrosis and Hypertrophy Through Activating Akt/mTOR and NFκB Signaling PathwaysCLINICAL PERSPECTIVE
Qingwei David Zhao, Suryavathi Viswanadhapalli, Paul Williams, Qian Shi, Chunyan Tan, Xiaolan Yi, Basant Bhandari and Hanna E. Abboud

Circulation. 2015;131:643-655, originally published January 14, 2015
https://doi.org/10.1161/CIRCULATIONAHA.114.011079

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Cellular and Molecular Mechanisms of Atrial Arrhythmogenesis in Patients With Paroxysmal Atrial FibrillationCLINICAL PERSPECTIVE
Niels Voigt, Jordi Heijman, Qiongling Wang, David Y. Chiang, Na Li, Matthias Karck, Xander H.T. Wehrens, Stanley Nattel and Dobromir Dobrev

Circulation. 2014;129:145-156, originally published January 13, 2014
https://doi.org/10.1161/CIRCULATIONAHA.113.006641

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Intramyocardial Adiposity After Myocardial InfarctionClinical PerspectiveNew Implications of a Substrate for Ventricular Tachycardia
Jim Pouliopoulos, William W.B. Chik, Ajita Kanthan, Gopal Sivagangabalan, Michael A. Barry, Peter N.A. Fahmy, Christine Midekin, Juntang Lu, Eddy Kizana, Stuart P. Thomas, Aravinda Thiagalingam and Pramesh Kovoor

Circulation. 2013;128:2296-2308, originally published November 18, 2013
https://doi.org/10.1161/CIRCULATIONAHA.113.002238

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“Assisted” Reshaping of the Fetal Heart?
Paul Leeson and Baskaran Thilaganathan

Circulation. 2013;128:1398-1399, originally published September 23, 2013
https://doi.org/10.1161/CIRCULATIONAHA.113.005375

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A Systems Approach to Designing Effective Clinical Trials Using Simulations
Vincent A. Fusaro, Prasad Patil, Chih-Lin Chi, Charles F. Contant and Peter J. Tonellato

Circulation. 2013;127:517-526, originally published January 28, 2013
https://doi.org/10.1161/CIRCULATIONAHA.112.123034

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Ca²⁺/Calmodulin-Dependent Protein Kinase II–Based Regulation of Voltage-Gated Na⁺ Channel in Cardiac DiseaseClinical Perspective
Olha M. Koval, Jedidiah S. Snyder, Roseanne M. Wolf, Ryan E. Pavlovicz, Patric Glynn, Jerry Curran, Nicholas D. Leymaster, Wen Dun, Patrick J. Wright, Natalia Cardona, Lan Qian, Colleen C. Mitchell, Penelope A. Boyden, Philip F. Binkley, Chenglong Li, Mark E. Anderson, Peter J. Mohler and Thomas J. Hund

Circulation. 2012;126:2084-2094, originally published October 22, 2012
https://doi.org/10.1161/CIRCULATIONAHA.112.105320

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Atrial FibrillationCurrent Knowledge and Future Directions in Epidemiology and Genomics
Jared W. Magnani, Michiel Rienstra, Honghuang Lin, Moritz F. Sinner, Steven A. Lubitz, David D. McManus, Josée Dupuis, Patrick T. Ellinor and Emelia J. Benjamin

Circulation. 2011;124:1982-1993, originally published October 31, 2011
https://doi.org/10.1161/CIRCULATIONAHA.111.039677

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Response to Letter Regarding Article, “Differential Cardiac Remodeling in Preload Versus Afterload”
Karl Toischer, Adam G. Rokita, Bernhard Unsöld, Samuel Sossalla, Alexander Becker, Tim Seidler, Cornelia Grebe, Lena Preuß, Shamindra N. Gupta, Kathie Schmidt, Stephan E. Lehnart, Katrin Schäfer, Lars S. Maier, Gerd Hasenfuss, Wuqiang Zhu, Sean P. Reuter, Loren J. Field, Georgios Kararigas, Vera Regitz-Zagrosek, Nils Teucher, Martina Krüger, Wolfgang A. Linke and Johannes Backs

Circulation. 2011;123:e421, originally published April 25, 2011
https://doi.org/10.1161/CIRCULATIONAHA.110.017566

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