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Prourokinase Mutant That Induces Highly Effective Clot Lysis Without Interfering With Hemostasis
Jian-Ning Liu, Jian-Xia Liu, Bei-fang Liu, Ziyong Sun, Jian-Ling Zuo, Pei-xiang Zhang, Jing Zhang, Yu-hong Chen, Victor Gurewich

Circulation Research April 2002, 90 (7) 757-763; DOI: https://doi.org/10.1161/01.RES.0000014825.71092.BD

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Table 1.
By Jian-Ning Liu, Jian-Xia Liu, Bei-fang Liu, Ziyong Sun, Jian-Ling Zuo, Pei-xiang Zhang, Jing Zhang, Yu-hong Chen and Victor Gurewich

Kinetics Analysis of S2444 Amidolysis by proUK, Single-Chain M5, UK, and tc-M5 and Glu-Plasminogen Activation by UK and tc-M5Show More

Kinetics Analysis of S2444 Amidolysis by proUK, Single-Chain M5, UK, and tc-M5 and Glu-Plasminogen Activation by UK and tc-M5Show Less
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Prourokinase Mutant That Induces Highly Effective Clot Lysis Without Interfering With Hemostasis
Jian-Ning Liu, Jian-Xia Liu, Bei-fang Liu, Ziyong Sun, Jian-Ling Zuo, Pei-xiang Zhang, Jing Zhang, Yu-hong Chen, Victor Gurewich

Circulation Research April 2002, 90 (7) 757-763; DOI: https://doi.org/10.1161/01.RES.0000014825.71092.BD

By Jian-Ning Liu, Jian-Xia Liu, Bei-fang Liu, Ziyong Sun, Jian-Ling Zuo, Pei-xiang Zhang, Jing Zhang, Yu-hong Chen and Victor Gurewich

Figure 1. Plasminogen activation by proUK (solid line) or M5 (broken line) from a mixture o...
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Figure 1. Plasminogen activation by proUK (solid line) or M5 (broken line) from a mixture of Glu-plasminogen (2 μmol/L), S2251 (1.5 mmol/L), and proUK or M5 (0.075 nmol/L). The activity curve, taken from a microtiter plate reader, shows that compared with proUK, M5 has a longer lag phase but that this is followed by a much steeper slope, reflecting its more rapid tc reaction rate.
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Prourokinase Mutant That Induces Highly Effective Clot Lysis Without Interfering With Hemostasis
Jian-Ning Liu, Jian-Xia Liu, Bei-fang Liu, Ziyong Sun, Jian-Ling Zuo, Pei-xiang Zhang, Jing Zhang, Yu-hong Chen, Victor Gurewich

Circulation Research April 2002, 90 (7) 757-763; DOI: https://doi.org/10.1161/01.RES.0000014825.71092.BD

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Table 2.
By Jian-Ning Liu, Jian-Xia Liu, Bei-fang Liu, Ziyong Sun, Jian-Ling Zuo, Pei-xiang Zhang, Jing Zhang, Yu-hong Chen and Victor Gurewich

Glu-Plasminogen (2 μmol/L) Activation by Plasmin-Resistant Ala158-oroUK or Ala158-M5 (1 nmol/L) in the Presence of CofactorsShow More

Glu-Plasminogen (2 μmol/L) Activation by Plasmin-Resistant Ala158-oroUK or Ala158-M5 (1 nmol/L) in the Presence of CofactorsShow Less
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Prourokinase Mutant That Induces Highly Effective Clot Lysis Without Interfering With Hemostasis
Jian-Ning Liu, Jian-Xia Liu, Bei-fang Liu, Ziyong Sun, Jian-Ling Zuo, Pei-xiang Zhang, Jing Zhang, Yu-hong Chen, Victor Gurewich

Circulation Research April 2002, 90 (7) 757-763; DOI: https://doi.org/10.1161/01.RES.0000014825.71092.BD

By Jian-Ning Liu, Jian-Xia Liu, Bei-fang Liu, Ziyong Sun, Jian-Ling Zuo, Pei-xiang Zhang, Jing Zhang, Yu-hong Chen and Victor Gurewich

Figure 2. In vitro lysis of ¹²⁵I-labeled plasma clots (0.2 mL) in a plasma milie...
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Figure 2. In vitro lysis of ¹²⁵I-labeled plasma clots (0.2 mL) in a plasma milieu (4 mL) by M5 (0.5 to 5 μg/mL) (A) or proUK (0.5 to 1.5 μg/mL) (B) over a fibrin-specific (<25% fibrinogen degradation) dose range. The percent clot lysis was determined from the radioactivity released into the plasma. The maximal rate of lysis, as reflected by the steepest slope, was 64% per hour for M5 and 41% per hour for proUK.
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Prourokinase Mutant That Induces Highly Effective Clot Lysis Without Interfering With Hemostasis
Jian-Ning Liu, Jian-Xia Liu, Bei-fang Liu, Ziyong Sun, Jian-Ling Zuo, Pei-xiang Zhang, Jing Zhang, Yu-hong Chen, Victor Gurewich

Circulation Research April 2002, 90 (7) 757-763; DOI: https://doi.org/10.1161/01.RES.0000014825.71092.BD

By Jian-Ning Liu, Jian-Xia Liu, Bei-fang Liu, Ziyong Sun, Jian-Ling Zuo, Pei-xiang Zhang, Jing Zhang, Yu-hong Chen and Victor Gurewich

Figure 3. In vivo lysis of ¹²⁵I-labeled whole blood clots in the dog. The radioa...
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Figure 3. In vivo lysis of ¹²⁵I-labeled whole blood clots in the dog. The radioactivity in plasma samples (mean±SD) obtained at intervals is shown. The number of dogs in each group is shown in parentheses, and the infusate (saline, proUK, tPA, or M5) and infusion rate (μg/kg per minute) are indicated.
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Prourokinase Mutant That Induces Highly Effective Clot Lysis Without Interfering With Hemostasis
Jian-Ning Liu, Jian-Xia Liu, Bei-fang Liu, Ziyong Sun, Jian-Ling Zuo, Pei-xiang Zhang, Jing Zhang, Yu-hong Chen, Victor Gurewich

Circulation Research April 2002, 90 (7) 757-763; DOI: https://doi.org/10.1161/01.RES.0000014825.71092.BD

By Jian-Ning Liu, Jian-Xia Liu, Bei-fang Liu, Ziyong Sun, Jian-Ling Zuo, Pei-xiang Zhang, Jing Zhang, Yu-hong Chen and Victor Gurewich

Figure 4. BT (mean±SD) in dogs (number in parentheses) infused with saline, tPA, proUK, or...
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Figure 4. BT (mean±SD) in dogs (number in parentheses) infused with saline, tPA, proUK, or M5 (60 μg/kg per minute).
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Prourokinase Mutant That Induces Highly Effective Clot Lysis Without Interfering With Hemostasis
Jian-Ning Liu, Jian-Xia Liu, Bei-fang Liu, Ziyong Sun, Jian-Ling Zuo, Pei-xiang Zhang, Jing Zhang, Yu-hong Chen, Victor Gurewich

Circulation Research April 2002, 90 (7) 757-763; DOI: https://doi.org/10.1161/01.RES.0000014825.71092.BD

By Jian-Ning Liu, Jian-Xia Liu, Bei-fang Liu, Ziyong Sun, Jian-Ling Zuo, Pei-xiang Zhang, Jing Zhang, Yu-hong Chen and Victor Gurewich

Figure 5. Total bleeding (mean±SD), as measured by the total number of gauze pads used to a...
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Figure 5. Total bleeding (mean±SD), as measured by the total number of gauze pads used to absorb the blood from the BT wounds in the dogs infused with saline, tPA, proUK, or M5.
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Prourokinase Mutant That Induces Highly Effective Clot Lysis Without Interfering With Hemostasis
Jian-Ning Liu, Jian-Xia Liu, Bei-fang Liu, Ziyong Sun, Jian-Ling Zuo, Pei-xiang Zhang, Jing Zhang, Yu-hong Chen, Victor Gurewich

Circulation Research April 2002, 90 (7) 757-763; DOI: https://doi.org/10.1161/01.RES.0000014825.71092.BD

By Jian-Ning Liu, Jian-Xia Liu, Bei-fang Liu, Ziyong Sun, Jian-Ling Zuo, Pei-xiang Zhang, Jing Zhang, Yu-hong Chen and Victor Gurewich

Figure 6. Clot lysis, fibrinogen, and BT in 4 monkeys infused with M5 (60 μg/kg per minute)...
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Figure 6. Clot lysis, fibrinogen, and BT in 4 monkeys infused with M5 (60 μg/kg per minute). The mean±SD values at baseline (0), 30, 45, and 60 minutes are shown. The results are presented as a percentage of the baseline (0% or 100%) value. The 2 saline-infused monkeys had ≈8% clot lysis at 60 minutes (not shown).
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Prourokinase Mutant That Induces Highly Effective Clot Lysis Without Interfering With Hemostasis
Jian-Ning Liu, Jian-Xia Liu, Bei-fang Liu, Ziyong Sun, Jian-Ling Zuo, Pei-xiang Zhang, Jing Zhang, Yu-hong Chen and Victor Gurewich

Circulation Research. 2002;90:757-763, originally published March 7, 2002
https://doi.org/10.1161/01.RES.0000014825.71092.BD

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Prourokinase Mutant That Induces Highly Effective Clot Lysis Without Interfering With Hemostasis
Jian-Ning Liu, Jian-Xia Liu, Bei-fang Liu, Ziyong Sun, Jian-Ling Zuo, Pei-xiang Zhang, Jing Zhang, Yu-hong Chen, Victor Gurewich

Circulation Research April 2002, 90 (7) 757-763; DOI: https://doi.org/10.1161/01.RES.0000014825.71092.BD

View table
Table 1.
By Jian-Ning Liu, Jian-Xia Liu, Bei-fang Liu, Ziyong Sun, Jian-Ling Zuo, Pei-xiang Zhang, Jing Zhang, Yu-hong Chen and Victor Gurewich

Kinetics Analysis of S2444 Amidolysis by proUK, Single-Chain M5, UK, and tc-M5 and Glu-Plasminogen Activation by UK and tc-M5Show More

Kinetics Analysis of S2444 Amidolysis by proUK, Single-Chain M5, UK, and tc-M5 and Glu-Plasminogen Activation by UK and tc-M5Show Less