Search for author "Zhaohua Cai"
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- You have accessRestricted accessEstrogen-Like Compounds for Ischemic NeuroprotectionJames W. Simpkins, Shao-Hua Yang, Ran Liu, Evelyn Perez, Zu Yun Cai, Douglas F. Covey and Pattie S. GreenStroke. 2004;35:2648-2651, originally published October 28, 2004https://doi.org/10.1161/01.STR.0000143734.59507.88
- You have accessEstrogen-Like Compounds for Ischemic NeuroprotectionJames W. Simpkins, Shao-Hua Yang, Ran Liu, Evelyn Perez, Zu Yun Cai, Douglas F. Covey, Pattie S. GreenStroke November 2004, 35 (11 suppl 1) 2648-2651; DOI: https://doi.org/10.1161/01.STR.0000143734.59507.88
- You have accessEstrogen-Like Compounds for Ischemic NeuroprotectionJames W. Simpkins, Shao-Hua Yang, Ran Liu, Evelyn Perez, Zu Yun Cai, Douglas F. Covey, Pattie S. GreenStroke November 2004, 35 (11 suppl 1) 2648-2651; DOI: https://doi.org/10.1161/01.STR.0000143734.59507.88Figure 2. Effects of selective estrogen analogues on (A) glutamate (20 mmol/L) toxicity in HT-22 cells and (B) on binding to human cloned estrogen rec...Show MoreFigure 2. Effects of selective estrogen analogues on (A) glutamate (20 mmol/L) toxicity in HT-22 cells and (B) on binding to human cloned estrogen receptor (ER)-α. In parentheses are (A) ED50 values for neuroprotection and (B) IC50 values for inhibition of binding of estradiol to ERα; n.p. indicates no protection; n.b. indicates no binding was detected over the concentration range studied. When standard error of mean (SEM) bars are not shown, they are smaller than the symbol used to depict the mean value.Show Less
- You have accessEstrogen-Like Compounds for Ischemic NeuroprotectionJames W. Simpkins, Shao-Hua Yang, Ran Liu, Evelyn Perez, Zu Yun Cai, Douglas F. Covey, Pattie S. GreenStroke November 2004, 35 (11 suppl 1) 2648-2651; DOI: https://doi.org/10.1161/01.STR.0000143734.59507.88Figure 3. Effects of 17β-estradiol (E2) and the enantiomer of 17β-estradiol (ent-E2) on infarct size in ovariectomized rats. Also depicted are represe...Show MoreFigure 3. Effects of 17β-estradiol (E2) and the enantiomer of 17β-estradiol (ent-E2) on infarct size in ovariectomized rats. Also depicted are representative photographs of TTC-stained brain sections from an animal in each treatment group. *P<0.05 vs oil group. E2 or ent-E2 was administered subcutaneously in oil (100 μg/kg) 2 hours before transient (1 hour) middle cerebral artery (MCA) occlusion. Modified from Reference 30, with permission.Show Less
- You have accessEstrogen-Like Compounds for Ischemic NeuroprotectionJames W. Simpkins, Shao-Hua Yang, Ran Liu, Evelyn Perez, Zu Yun Cai, Douglas F. Covey, Pattie S. GreenStroke November 2004, 35 (11 suppl 1) 2648-2651; DOI: https://doi.org/10.1161/01.STR.0000143734.59507.88Figure 4. Effects of 17β-estradiol (E2) and ZYC-3 on infarct size in ovariectomized rats. **P<0.05 versus OVX control group. E2 (100 μg/kg) was adm...Show MoreFigure 4. Effects of 17β-estradiol (E2) and ZYC-3 on infarct size in ovariectomized rats. **P<0.05 versus OVX control group. E2 (100 μg/kg) was administered in oil 2 hours before and ZYC-3 (100 μg/kg) in hydroxypropyl-β-cyclodextrin immediately before transient (1 hour) middle cerebral artery occlusion. Modified from Reference 31, with permission.Show Less
- You have accessEstrogen-Like Compounds for Ischemic NeuroprotectionJames W. Simpkins, Shao-Hua Yang, Ran Liu, Evelyn Perez, Zu Yun Cai, Douglas F. Covey, Pattie S. GreenStroke November 2004, 35 (11 suppl 1) 2648-2651; DOI: https://doi.org/10.1161/01.STR.0000143734.59507.88Effects of Estrone, ZYC-23, and ZYC-26, on Uterine Weights and Infarct Volume After Transient Middle Cerebral Artery Occlusion in Ovariectomized RatsShow MoreEffects of Estrone, ZYC-23, and ZYC-26, on Uterine Weights and Infarct Volume After Transient Middle Cerebral Artery Occlusion in Ovariectomized RatsShow Less



