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  • Control of Blood Pressure, Appetite, and Glucose by Leptin in Mice Lacking Leptin Receptors in Proopiomelanocortin Neurons
    Jussara M. do Carmo, Alexandre A. da Silva, Zhengwei Cai, Shuying Lin, John H. Dubinion, John E. Hall
    Hypertension May 2011, 57 (5) 918-926; DOI: https://doi.org/10.1161/HYPERTENSIONAHA.110.161349
    Figure 1.
    Figure 1.
    Top, POMC-positive neurons (arrows in A and D) and LepR-positive cells (arrows in B and E) were detected in the ARC of LepRflox/flox and LepRflox/flox...Show More
  • Control of Blood Pressure, Appetite, and Glucose by Leptin in Mice Lacking Leptin Receptors in Proopiomelanocortin Neurons
    Jussara M. do Carmo, Alexandre A. da Silva, Zhengwei Cai, Shuying Lin, John H. Dubinion, John E. Hall
    Hypertension May 2011, 57 (5) 918-926; DOI: https://doi.org/10.1161/HYPERTENSIONAHA.110.161349
    View table
    Table.
    Effects of Chronic Leptin Infusion (2 μg/kg per Minute, IV) on Body Weight, Body Length, Epididymal Fat Weight, Water Intake, and Urine VolumeShow More
  • Control of Blood Pressure, Appetite, and Glucose by Leptin in Mice Lacking Leptin Receptors in Proopiomelanocortin Neurons
    Jussara M. do Carmo, Alexandre A. da Silva, Zhengwei Cai, Shuying Lin, John H. Dubinion, John E. Hall
    Hypertension May 2011, 57 (5) 918-926; DOI: https://doi.org/10.1161/HYPERTENSIONAHA.110.161349
    Figure 2.
    Figure 2.
    Body weight curve of male WT (n=5), LepRflox/flox (n=5), and LepRflox/flox/POMC-Cre (n=5) mice. *P<0.05 vs WT and LepRflox/flox mice.Show More
  • Control of Blood Pressure, Appetite, and Glucose by Leptin in Mice Lacking Leptin Receptors in Proopiomelanocortin Neurons
    Jussara M. do Carmo, Alexandre A. da Silva, Zhengwei Cai, Shuying Lin, John H. Dubinion, John E. Hall
    Hypertension May 2011, 57 (5) 918-926; DOI: https://doi.org/10.1161/HYPERTENSIONAHA.110.161349
    Figure 3.
    Figure 3.
    A, Response to acute leptin injection (10 mg/kg, IP) on food intake. *P<0.05 vs saline-treated group. B, Response to chronic leptin infusion (2 μg/...Show More
  • Control of Blood Pressure, Appetite, and Glucose by Leptin in Mice Lacking Leptin Receptors in Proopiomelanocortin Neurons
    Jussara M. do Carmo, Alexandre A. da Silva, Zhengwei Cai, Shuying Lin, John H. Dubinion, John E. Hall
    Hypertension May 2011, 57 (5) 918-926; DOI: https://doi.org/10.1161/HYPERTENSIONAHA.110.161349
    Figure 4.
    Figure 4.
    Response to chronic leptin infusion (2 μg/kg per minute) for 7 days on (A) 24-hour average MAP and (B) HR in WT (n=6) LepRflox/flox (n=4) and LepRflox...Show More
  • Control of Blood Pressure, Appetite, and Glucose by Leptin in Mice Lacking Leptin Receptors in Proopiomelanocortin Neurons
    Jussara M. do Carmo, Alexandre A. da Silva, Zhengwei Cai, Shuying Lin, John H. Dubinion, John E. Hall
    Hypertension May 2011, 57 (5) 918-926; DOI: https://doi.org/10.1161/HYPERTENSIONAHA.110.161349
    Figure 5.
    Figure 5.
    A, Changes in MAP, (B) HR, and (C) area under curve (AUC) for blood pressure during acute air-jet stress and recovery period in WT (n=5) and LepRflox/...Show More
  • Control of Blood Pressure, Appetite, and Glucose by Leptin in Mice Lacking Leptin Receptors in Proopiomelanocortin Neurons
    Jussara M. do Carmo, Alexandre A. da Silva, Zhengwei Cai, Shuying Lin, John H. Dubinion, John E. Hall
    Hypertension May 2011, 57 (5) 918-926; DOI: https://doi.org/10.1161/HYPERTENSIONAHA.110.161349
    Figure 6.
    Figure 6.
    Response to chronic leptin infusion (2 μg/kg per minute) for 7 days on (A) Vo2 and (B) motor activity in LepRflox/flox/POMC-Cre (n=6) and WT (n=5) mic...Show More
  • Control of Blood Pressure, Appetite, and Glucose by Leptin in Mice Lacking Leptin Receptors in Proopiomelanocortin Neurons
    Jussara M. do Carmo, Alexandre A. da Silva, Zhengwei Cai, Shuying Lin, John H. Dubinion, John E. Hall
    Hypertension May 2011, 57 (5) 918-926; DOI: https://doi.org/10.1161/HYPERTENSIONAHA.110.161349
    Figure 7.
    Figure 7.
    A, Plasma glucose, (B) insulin, and (C) leptin levels in WT (n=6) and LepRflox/flox/POMC-Cre (n=7) mice during control, day 7 of leptin infusion, and...Show More
  • Control of Blood Pressure, Appetite, and Glucose by Leptin in Mice Lacking Leptin Receptors in Proopiomelanocortin Neurons
    Jussara M. do Carmo, Alexandre A. da Silva, Zhengwei Cai, Shuying Lin, John H. Dubinion, John E. Hall
    Hypertension May 2011, 57 (5) 918-926; DOI: https://doi.org/10.1161/HYPERTENSIONAHA.110.161349
    Figure 1.
    Figure 1.
    Top, POMC-positive neurons (arrows in A and D) and LepR-positive cells (arrows in B and E) were detected in the ARC of LepRflox/flox and LepRflox/flox...Show More
  • Control of Blood Pressure, Appetite, and Glucose by Leptin in Mice Lacking Leptin Receptors in Proopiomelanocortin Neurons
    Jussara M. do Carmo, Alexandre A. da Silva, Zhengwei Cai, Shuying Lin, John H. Dubinion, John E. Hall
    Hypertension May 2011, 57 (5) 918-926; DOI: https://doi.org/10.1161/HYPERTENSIONAHA.110.161349
    View table
    Table.
    Effects of Chronic Leptin Infusion (2 μg/kg per Minute, IV) on Body Weight, Body Length, Epididymal Fat Weight, Water Intake, and Urine VolumeShow More

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