Growth curves of blood pressure (BP) by race–sex groups. Curve parameters were all significantly different from 0 (P<0.001) except −0.05 (P=0.023) and 0.0001 (P=0.965) for diastolic BP (DBP) in black men (see detailed information on the curve parameters in Table S1). SBP indicates systolic BP.
By WeiShen, TaoZhang, ShengxuLi, HuijieZhang, BoXi, HongbingShen, CamiloFernandez, LydiaBazzano, JiangHe and WeiChen
Odds ratio (OR) and 95% confidence interval (CI) of model-estimated childhood systolic blood pressure (SBP) levels and linear slopes for adult hyperte...Show More
Odds ratio (OR) and 95% confidence interval (CI) of model-estimated childhood systolic blood pressure (SBP) levels and linear slopes for adult hypertension by childhood age and race–sex groups. For SBP levels, race and sex, adult age, smoking and alcohol use, body mass index (BMI) levels were included as covariates. For SBP linear slopes, race and sex, adult age, smoking and alcohol use, levels and slopes of BMI, and levels of SBP were included as covariates.Show Less
Covariates-adjusted mean values of adult LVMI by childhood and adulthood BMI and SBP status. Covariates included adult age, race, and sex. BMI indicates body mass index; LVMI, left ventricular mass index; and SBP, systolic blood pressure. *P<0.01 vs low-low group.
Mediation effect of adult BMI and SBP on the childhood BMI–Adult LVMI association. A, Mediation effect of adult BMI. B, Mediation effect of adult SBP. *P<0.05 and **P<0.01. aTotal and net mediation effect of adult BMI and SBP after additional adjustment for childhood SBP. bNet mediation effect of adult BMI after adjustment for adult SBP. cNet mediation effect of adult SBP after adjustment for adult BMI. β indicates standardized regression coefficient; β1, indirect effect 1; β2, indirect effect 2; βDir, direct effect; βInd, total indirect effect; βTot, total effect; AUC, area under the curve; BMI, body mass index; LVMI, left ventricular mass index; and SBP, systolic blood pressure.
Mediation effect of long-term burden of SBP on the association between long-term burden of BMI and adult LVMI. A, Mediation effect of total SBP AUC. B, Mediation effect of incremental SBP AUC. β indicates standardized regression coefficient; β1, indirect effect 1; β2, indirect effect 2; βDir, direct effect; βInd, total indirect effect; βTot, total effect; AUC, area under the curve; BMI, body mass index; LVMI, left ventricular mass index; and SBP, systolic blood pressure. *P<0.05, **P<0.01.
