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  Long-Term Excessive Body Weight and Adult Left Ventricular Hypertrophy Are Linked Through Later-Life Body Size and Blood PressureNovelty and SignificanceThe Bogalusa Heart Study

  Huijie Zhang, Tao Zhang, Shengxu Li, Yajun Guo, Wei Shen, Camilo Fernandez, Emily Harville, Lydia A. Bazzano, Elaine M. Urbina, Jiang He and Wei Chen

  Circulation Research. 2017;120:1614-1621, originally published February 23, 2017

  https://doi.org/10.1161/CIRCRESAHA.116.310421

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  Long-Term Excessive Body Weight and Adult Left Ventricular Hypertrophy Are Linked Through Later-Life Body Size and Blood PressureNovelty and Significance

  Huijie Zhang, Tao Zhang, Shengxu Li, Yajun Guo, Wei Shen, Camilo Fernandez, Emily Harville, Lydia A. Bazzano, Elaine M. Urbina, Jiang He, Wei Chen

  Circulation Research May 2017, 120 (10) 1614-1621; DOI: https://doi.org/10.1161/CIRCRESAHA.116.310421

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  Table 1.

  By Huijie Zhang, Tao Zhang, Shengxu Li, Yajun Guo, Wei Shen, Camilo Fernandez, Emily Harville, Lydia A. Bazzano, Elaine M. Urbina, Jiang He and Wei Chen

  Characteristics (Mean±SD) of Study Variables by Race and SexShow More

  Characteristics (Mean±SD) of Study Variables by Race and SexShow Less
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  Long-Term Excessive Body Weight and Adult Left Ventricular Hypertrophy Are Linked Through Later-Life Body Size and Blood PressureNovelty and Significance

  Huijie Zhang, Tao Zhang, Shengxu Li, Yajun Guo, Wei Shen, Camilo Fernandez, Emily Harville, Lydia A. Bazzano, Elaine M. Urbina, Jiang He, Wei Chen

  Circulation Research May 2017, 120 (10) 1614-1621; DOI: https://doi.org/10.1161/CIRCRESAHA.116.310421

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  Table 2.

  By Huijie Zhang, Tao Zhang, Shengxu Li, Yajun Guo, Wei Shen, Camilo Fernandez, Emily Harville, Lydia A. Bazzano, Elaine M. Urbina, Jiang He and Wei Chen

  Total Effect of BMI on Adult LVM Index and LVH Geometry in Linear and Logistic Regression Analyses, Adjusted for Covariates* in the ModelShow More

  Total Effect of BMI on Adult LVM Index and LVH Geometry in Linear and Logistic Regression Analyses, Adjusted for Covariates* in the ModelShow Less
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  Long-Term Excessive Body Weight and Adult Left Ventricular Hypertrophy Are Linked Through Later-Life Body Size and Blood PressureNovelty and Significance

  Huijie Zhang, Tao Zhang, Shengxu Li, Yajun Guo, Wei Shen, Camilo Fernandez, Emily Harville, Lydia A. Bazzano, Elaine M. Urbina, Jiang He, Wei Chen

  Circulation Research May 2017, 120 (10) 1614-1621; DOI: https://doi.org/10.1161/CIRCRESAHA.116.310421

  

  Figure 1.

  By Huijie Zhang, Tao Zhang, Shengxu Li, Yajun Guo, Wei Shen, Camilo Fernandez, Emily Harville, Lydia A. Bazzano, Elaine M. Urbina, Jiang He and Wei Chen

  Covariates-adjusted mean values of adult LVMI by childhood and adulthood BMI and SBP status...

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  Covariates-adjusted mean values of adult LVMI by childhood and adulthood BMI and SBP status. Covariates included adult age, race, and sex. BMI indicates body mass index; LVMI, left ventricular mass index; and SBP, systolic blood pressure. *P<0.01 vs low-low group.

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  Long-Term Excessive Body Weight and Adult Left Ventricular Hypertrophy Are Linked Through Later-Life Body Size and Blood PressureNovelty and Significance

  Huijie Zhang, Tao Zhang, Shengxu Li, Yajun Guo, Wei Shen, Camilo Fernandez, Emily Harville, Lydia A. Bazzano, Elaine M. Urbina, Jiang He, Wei Chen

  Circulation Research May 2017, 120 (10) 1614-1621; DOI: https://doi.org/10.1161/CIRCRESAHA.116.310421

  

  Figure 2.

  By Huijie Zhang, Tao Zhang, Shengxu Li, Yajun Guo, Wei Shen, Camilo Fernandez, Emily Harville, Lydia A. Bazzano, Elaine M. Urbina, Jiang He and Wei Chen

  Mediation effect of adult BMI and SBP on the childhood BMI–Adult LVMI association. ...

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  Mediation effect of adult BMI and SBP on the childhood BMI–Adult LVMI association. A, Mediation effect of adult BMI. B, Mediation effect of adult SBP. *P<0.05 and **P<0.01. ^aTotal and net mediation effect of adult BMI and SBP after additional adjustment for childhood SBP. ^bNet mediation effect of adult BMI after adjustment for adult SBP. ^cNet mediation effect of adult SBP after adjustment for adult BMI. β indicates standardized regression coefficient; β₁, indirect effect 1; β₂, indirect effect 2; β_Dir, direct effect; β_Ind, total indirect effect; β_Tot, total effect; AUC, area under the curve; BMI, body mass index; LVMI, left ventricular mass index; and SBP, systolic blood pressure.

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  Long-Term Excessive Body Weight and Adult Left Ventricular Hypertrophy Are Linked Through Later-Life Body Size and Blood PressureNovelty and Significance

  Huijie Zhang, Tao Zhang, Shengxu Li, Yajun Guo, Wei Shen, Camilo Fernandez, Emily Harville, Lydia A. Bazzano, Elaine M. Urbina, Jiang He, Wei Chen

  Circulation Research May 2017, 120 (10) 1614-1621; DOI: https://doi.org/10.1161/CIRCRESAHA.116.310421

  

  Figure 3.

  By Huijie Zhang, Tao Zhang, Shengxu Li, Yajun Guo, Wei Shen, Camilo Fernandez, Emily Harville, Lydia A. Bazzano, Elaine M. Urbina, Jiang He and Wei Chen

  Mediation effect of long-term burden of SBP on the association between long-term burden of BMI and a...

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  Mediation effect of long-term burden of SBP on the association between long-term burden of BMI and adult LVMI. A, Mediation effect of total SBP AUC. B, Mediation effect of incremental SBP AUC. β indicates standardized regression coefficient; β₁, indirect effect 1; β₂, indirect effect 2; β_Dir, direct effect; β_Ind, total indirect effect; β_Tot, total effect; AUC, area under the curve; BMI, body mass index; LVMI, left ventricular mass index; and SBP, systolic blood pressure. *P<0.05, **P<0.01.

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  Long-Term Excessive Body Weight and Adult Left Ventricular Hypertrophy Are Linked Through Later-Life Body Size and Blood PressureNovelty and Significance

  Huijie Zhang, Tao Zhang, Shengxu Li, Yajun Guo, Wei Shen, Camilo Fernandez, Emily Harville, Lydia A. Bazzano, Elaine M. Urbina, Jiang He, Wei Chen

  Circulation Research May 2017, 120 (10) 1614-1621; DOI: https://doi.org/10.1161/CIRCRESAHA.116.310421

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  Table 3.

  By Huijie Zhang, Tao Zhang, Shengxu Li, Yajun Guo, Wei Shen, Camilo Fernandez, Emily Harville, Lydia A. Bazzano, Elaine M. Urbina, Jiang He and Wei Chen

  Mediation Analysis With LVH Geometry as the Outcome in Association With BMI and SBPShow More

  Mediation Analysis With LVH Geometry as the Outcome in Association With BMI and SBPShow Less
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  Abstract 130: Arginine Methylation of Smad6 Defines Bone-morphogenetic-protein (BMP) Signaling Duration and Intensity

  JIAN WU, Olan Jackson-Weaver, Tingwei Zhang, Yongchao Gou and Jian Xu

  Circulation Research. 2016;119:A130
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  Abstract 107: Apocynin Attenuates Isoproterenol-induced Myocardial Injury: Implications For Targeting Nadph Oxidase In Myocardial Fibrogenesis

  Yu Chen, Jingang Cui, Qinbo Yang, Chenglin Jia, Minqi Xiong, Peiwei Wang and Teng Zhang

  Circulation Research. 2013;113:A107
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  Abstract P303: Panaxnotogensengsaponins Promotes Angiogenesis and Enhances the Buildup of Effective Coronary Collateral Circulation in Ischemic Myocardium

  Teng Zhang and Wen-jian Wang

  Circulation Research. 2011;109:AP303

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