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Search for author "Ron Simon"

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    Can Genes Modify Stroke Outcome and By What Mechanisms?
    Roger P. Simon, Robert Meller, An Zhou and David Henshall
    Stroke. 2012;43:286-291, originally published December 23, 2011
    https://doi.org/10.1161/STROKEAHA.111.622225
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    Can Genes Modify Stroke Outcome and By What Mechanisms?
    Roger P. Simon, Robert Meller, An Zhou, David Henshall
    Stroke January 2012, 43 (1) 286-291; DOI: https://doi.org/10.1161/STROKEAHA.111.622225
    Figure 1.
    Figure 1.
    Genes whose expression is uniquely increased/decreased in ischemic injury (left) or uniquely increased/decreased in ischemic tolerance (right) are cat...Show More
    Genes whose expression is uniquely increased/decreased in ischemic injury (left) or uniquely increased/decreased in ischemic tolerance (right) are categorized by biological function. In injury (stroke), a majority of regulated genes are expressed at higher levels. By contrast, in tolerance (protection), a majority of regulated genes are expressed at lower levels. Based on data from Stenzel-Poore et al, 2003.22Show Less
  • You have access
    Can Genes Modify Stroke Outcome and By What Mechanisms?
    Roger P. Simon, Robert Meller, An Zhou, David Henshall
    Stroke January 2012, 43 (1) 286-291; DOI: https://doi.org/10.1161/STROKEAHA.111.622225
    Figure 2.
    Figure 2.
    Analysis of genes regulated in stroke preceded by preconditioning with ischemia, lipopolysaccharide (LPS), or CpGs. Left, Thirteen genes were regulate...Show More
    Analysis of genes regulated in stroke preceded by preconditioning with ischemia, lipopolysaccharide (LPS), or CpGs. Left, Thirteen genes were regulated in all 3 conditions. Right, Promoter analysis identified 5 over-represented transcription response elements (TRE; red) that putatively regulate expression of the 13 genes (blue). Four of the TREs (IRF, IRF7, IRF8, ISRE) associate with interferon signaling. Modified from Stevens et al, 2011 with permission.35Show Less
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    Can Genes Modify Stroke Outcome and By What Mechanisms?
    Roger P. Simon, Robert Meller, An Zhou, David Henshall
    Stroke January 2012, 43 (1) 286-291; DOI: https://doi.org/10.1161/STROKEAHA.111.622225
    Figure 3.
    Figure 3.
    MiRNAs in ischemic tolerance. A, MiRNA screening reveals that the predominant response of miRNAs after preconditioning (P) is upregulation, versus dow...Show More
    MiRNAs in ischemic tolerance. A, MiRNA screening reveals that the predominant response of miRNAs after preconditioning (P) is upregulation, versus downregulation in ischemia (I) and tolerance (T). B, MeCP2 (methyl-CpG binding protein) immunostaining shows induction in the cortex 8 and 24 hours after preconditioning, consistent with decreased expression of MeCP2 miRNA. SH indicates sham; PC, preconditioning. C, Infarct is larger in tolerized MeCP2-null mice than in tolerized wild-type (Con) mice. Adapted, with permission, from Lusardi et al, 2010.36Show Less
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    Can Genes Modify Stroke Outcome and By What Mechanisms?
    Roger P. Simon, Robert Meller, An Zhou, David Henshall
    Stroke January 2012, 43 (1) 286-291; DOI: https://doi.org/10.1161/STROKEAHA.111.622225
    Figure 4.
    Figure 4.
    Top, Proposed bivalent, epigenetic mechanism for regulating the brain's response to ischemia. Increased PcG protein abundance suppresses transcription...Show More
    Top, Proposed bivalent, epigenetic mechanism for regulating the brain's response to ischemia. Increased PcG protein abundance suppresses transcription. Increased TrxG protein abundance activates transcription. Bottom, In tolerance (TOL), PcG proteins increase. In injurious ischemia (INJ), TrxG proteins increase. The balance between PcG and TrxG activity may determine the response to ischemia. Transcriptional suppression and tolerance may be induced by increasing PcG proteins, decreasing TrxG proteins, or a combination thereof. SH indicates sham; PC, preconditioning.Show Less
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