Search for author "Ron Simon"
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- You have accessRestricted accessCan Genes Modify Stroke Outcome and By What Mechanisms?Roger P. Simon, Robert Meller, An Zhou and David HenshallStroke. 2012;43:286-291, originally published December 23, 2011https://doi.org/10.1161/STROKEAHA.111.622225
- Figure 1.You have accessCan Genes Modify Stroke Outcome and By What Mechanisms?Roger P. Simon, Robert Meller, An Zhou, David HenshallStroke January 2012, 43 (1) 286-291; DOI: https://doi.org/10.1161/STROKEAHA.111.622225Genes whose expression is uniquely increased/decreased in ischemic injury (left) or uniquely increased/decreased in ischemic tolerance (right) are cat...Show MoreGenes whose expression is uniquely increased/decreased in ischemic injury (left) or uniquely increased/decreased in ischemic tolerance (right) are categorized by biological function. In injury (stroke), a majority of regulated genes are expressed at higher levels. By contrast, in tolerance (protection), a majority of regulated genes are expressed at lower levels. Based on data from Stenzel-Poore et al, 2003.22Show Less
- Figure 2.You have accessCan Genes Modify Stroke Outcome and By What Mechanisms?Roger P. Simon, Robert Meller, An Zhou, David HenshallStroke January 2012, 43 (1) 286-291; DOI: https://doi.org/10.1161/STROKEAHA.111.622225Analysis of genes regulated in stroke preceded by preconditioning with ischemia, lipopolysaccharide (LPS), or CpGs. Left, Thirteen genes were regulate...Show MoreAnalysis of genes regulated in stroke preceded by preconditioning with ischemia, lipopolysaccharide (LPS), or CpGs. Left, Thirteen genes were regulated in all 3 conditions. Right, Promoter analysis identified 5 over-represented transcription response elements (TRE; red) that putatively regulate expression of the 13 genes (blue). Four of the TREs (IRF, IRF7, IRF8, ISRE) associate with interferon signaling. Modified from Stevens et al, 2011 with permission.35Show Less
- Figure 3.You have accessCan Genes Modify Stroke Outcome and By What Mechanisms?Roger P. Simon, Robert Meller, An Zhou, David HenshallStroke January 2012, 43 (1) 286-291; DOI: https://doi.org/10.1161/STROKEAHA.111.622225MiRNAs in ischemic tolerance. A, MiRNA screening reveals that the predominant response of miRNAs after preconditioning (P) is upregulation, versus dow...Show MoreMiRNAs in ischemic tolerance. A, MiRNA screening reveals that the predominant response of miRNAs after preconditioning (P) is upregulation, versus downregulation in ischemia (I) and tolerance (T). B, MeCP2 (methyl-CpG binding protein) immunostaining shows induction in the cortex 8 and 24 hours after preconditioning, consistent with decreased expression of MeCP2 miRNA. SH indicates sham; PC, preconditioning. C, Infarct is larger in tolerized MeCP2-null mice than in tolerized wild-type (Con) mice. Adapted, with permission, from Lusardi et al, 2010.36Show Less
- Figure 4.You have accessCan Genes Modify Stroke Outcome and By What Mechanisms?Roger P. Simon, Robert Meller, An Zhou, David HenshallStroke January 2012, 43 (1) 286-291; DOI: https://doi.org/10.1161/STROKEAHA.111.622225Top, Proposed bivalent, epigenetic mechanism for regulating the brain's response to ischemia. Increased PcG protein abundance suppresses transcription...Show MoreTop, Proposed bivalent, epigenetic mechanism for regulating the brain's response to ischemia. Increased PcG protein abundance suppresses transcription. Increased TrxG protein abundance activates transcription. Bottom, In tolerance (TOL), PcG proteins increase. In injurious ischemia (INJ), TrxG proteins increase. The balance between PcG and TrxG activity may determine the response to ischemia. Transcriptional suppression and tolerance may be induced by increasing PcG proteins, decreasing TrxG proteins, or a combination thereof. SH indicates sham; PC, preconditioning.Show Less



