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  Ischemic PreconditioningIntroduction

  Antoine Hakim and Roger Simon

  Stroke. 2004;35:2675, originally published October 28, 2004

  https://doi.org/10.1161/01.STR.0000143238.24952.88

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  Genomics of Preconditioning

  Mary P. Stenzel-Poore, Susan L. Stevens and Roger P. Simon

  Stroke. 2004;35:2683-2686, originally published October 28, 2004

  https://doi.org/10.1161/01.STR.0000143735.89281.bb

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  Genomics of Preconditioning

  Mary P. Stenzel-Poore, Susan L. Stevens, Roger P. Simon

  Stroke November 2004, 35 (11 suppl 1) 2683-2686; DOI: https://doi.org/10.1161/01.STR.0000143735.89281.bb

  

  Figure 1. Ischemic preconditioning reduces infarct after injurious ischemia. Sixty minutes of MCAO alone (left) or 60 minutes of MCAO 72 hours after 1...Show More

  Figure 1. Ischemic preconditioning reduces infarct after injurious ischemia. Sixty minutes of MCAO alone (left) or 60 minutes of MCAO 72 hours after 15 minutes of preconditioning (right) were performed. Infarcts visualized with 2′3′5-triphenyltetrazolium chloride staining, and percent infarct measured using National Institutes of Health image. Values are mean percent infarcts±SEM, n=8 mice per group. *P<0.05, Student t test.Show Less
• You have access

  Genomics of Preconditioning

  Mary P. Stenzel-Poore, Susan L. Stevens, Roger P. Simon

  Stroke November 2004, 35 (11 suppl 1) 2683-2686; DOI: https://doi.org/10.1161/01.STR.0000143735.89281.bb

  

  Figure 2. Preconditioning and stroke alter gene expression. A, Cortices were harvested at the indicated times (small arrows). B and C, Venn diagrams i...Show More

  Figure 2. Preconditioning and stroke alter gene expression. A, Cortices were harvested at the indicated times (small arrows). B and C, Venn diagrams illustrate the number of regulated genes in each condition 3 hours (B) or 24 hours (C) after ischemia.Show Less
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  Genomics of Preconditioning

  Mary P. Stenzel-Poore, Susan L. Stevens, Roger P. Simon

  Stroke November 2004, 35 (11 suppl 1) 2683-2686; DOI: https://doi.org/10.1161/01.STR.0000143735.89281.bb

  

  Figure 3. Preconditioning alters the genomic response to stroke. Number of genes in various functional categories that are increased or decreased in i...Show More

  Figure 3. Preconditioning alters the genomic response to stroke. Number of genes in various functional categories that are increased or decreased in ischemic versus nonischemic hemispheres. Data do not include genes of unknown function.Show Less
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  Genomics of Preconditioning

  Mary P. Stenzel-Poore, Susan L. Stevens, Roger P. Simon

  Stroke November 2004, 35 (11 suppl 1) 2683-2686; DOI: https://doi.org/10.1161/01.STR.0000143735.89281.bb

  

  Figure 4. Preconditioning or preconditioning followed by damaging OGD decreases outward potassium currents and whole-cell conductance in an in vitro m...Show More

  Figure 4. Preconditioning or preconditioning followed by damaging OGD decreases outward potassium currents and whole-cell conductance in an in vitro model of tolerance. Rat cortical neuronal cells were exposed to OGD for 30 minutes. (preconditioning), or 30 minutes, followed 24 hours later by 120 minutes (preconditioning + damaging). A, Patch clamp (voltage-gated potassium currents) current density plot. Density of outward current in control neurons (white circles, n=21), neurons that received preconditioning OGD (white squares, n=19), and neurons that received preconditioning plus damaging OGD (black squares, n=9). *P<0.05. Student t test (unpaired) was used to compare points on different curves but activated by stepping to the same potential. B, Representative plots of whole-cell conductance (current–voltage relationship) measurements in control (white circles) and preconditioned (black circles) neurons by linear regression of the current–voltage relationship between −30 and 80 mV.Show Less
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  Genomics of Preconditioning

  Mary P. Stenzel-Poore, Susan L. Stevens, Roger P. Simon

  Stroke November 2004, 35 (11 suppl 1) 2683-2686; DOI: https://doi.org/10.1161/01.STR.0000143735.89281.bb

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  Ischemic Preconditioning Increases Bleeding TimeShow More

  Ischemic Preconditioning Increases Bleeding TimeShow Less
• You have accessRestricted access

  Ischemic PreconditioningIntroduction

  Antoine Hakim and Roger Simon

  Stroke. 2004;35:2675, originally published October 28, 2004

  https://doi.org/10.1161/01.STR.0000143238.24952.88

  Download PDF
• You have accessRestricted access

  Genomics of Preconditioning

  Mary P. Stenzel-Poore, Susan L. Stevens and Roger P. Simon

  Stroke. 2004;35:2683-2686, originally published October 28, 2004

  https://doi.org/10.1161/01.STR.0000143735.89281.bb

  Download PDF
• You have access

  Genomics of Preconditioning

  Mary P. Stenzel-Poore, Susan L. Stevens, Roger P. Simon

  Stroke November 2004, 35 (11 suppl 1) 2683-2686; DOI: https://doi.org/10.1161/01.STR.0000143735.89281.bb

  

  Figure 1. Ischemic preconditioning reduces infarct after injurious ischemia. Sixty minutes of MCAO alone (left) or 60 minutes of MCAO 72 hours after 1...Show More

  Figure 1. Ischemic preconditioning reduces infarct after injurious ischemia. Sixty minutes of MCAO alone (left) or 60 minutes of MCAO 72 hours after 15 minutes of preconditioning (right) were performed. Infarcts visualized with 2′3′5-triphenyltetrazolium chloride staining, and percent infarct measured using National Institutes of Health image. Values are mean percent infarcts±SEM, n=8 mice per group. *P<0.05, Student t test.Show Less

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