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Administration of Recombinant P-Selectin Glycoprotein Ligand Fc Fusion Protein Suppresses Inflammation and Neointimal Formation in Zucker Diabetic Rat Model
Zhongmin Zhou, Marc S. Penn, Farhad Forudi, Xiaorong Zhou, Khaldoun Tarakji, Eric J. Topol, A. Michael Lincoff and Kai Wang

Arteriosclerosis, Thrombosis, and Vascular Biology. 2002;22:1598-1603, originally published August 8, 2002
https://doi.org/10.1161/01.ATV.0000032676.20514.8F

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Administration of Recombinant P-Selectin Glycoprotein Ligand Fc Fusion Protein Suppresses Inflammation and Neointimal Formation in Zucker Diabetic Rat Model
Zhongmin Zhou, Marc S. Penn, Farhad Forudi, Xiaorong Zhou, Khaldoun Tarakji, Eric J. Topol, A. Michael Lincoff, Kai Wang

Arteriosclerosis, Thrombosis, and Vascular Biology October 2002, 22 (10) 1598-1603; DOI: https://doi.org/10.1161/01.ATV.0000032676.20514.8F

Figure 1. Photomicrographs of representative P-selectin immunostaining showing arteries fro...
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Figure 1. Photomicrographs of representative P-selectin immunostaining showing arteries from control and rPSGL-treated rats at 1, 3, and 7 days after balloon injury. A, Section from rat at day 1 showed positive P-selectin immunostaining. B, Section from rat at day 3 showed P-selectin staining around lumen. C, By day 7, more intense P-selectin staining was observed around lumen and extending into media. D through F, Sections from days 1, 3, and 7 in rPSGL-Ig–treated rats, showing significantly decreased P-selectin expression.
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Administration of Recombinant P-Selectin Glycoprotein Ligand Fc Fusion Protein Suppresses Inflammation and Neointimal Formation in Zucker Diabetic Rat Model
Zhongmin Zhou, Marc S. Penn, Farhad Forudi, Xiaorong Zhou, Khaldoun Tarakji, Eric J. Topol, A. Michael Lincoff, Kai Wang

Arteriosclerosis, Thrombosis, and Vascular Biology October 2002, 22 (10) 1598-1603; DOI: https://doi.org/10.1161/01.ATV.0000032676.20514.8F

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Table 1.
% Area Occupied by P-Selectin Positive Cells After Balloon Injury
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% Area Occupied by P-Selectin Positive Cells After Balloon Injury
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Administration of Recombinant P-Selectin Glycoprotein Ligand Fc Fusion Protein Suppresses Inflammation and Neointimal Formation in Zucker Diabetic Rat Model
Zhongmin Zhou, Marc S. Penn, Farhad Forudi, Xiaorong Zhou, Khaldoun Tarakji, Eric J. Topol, A. Michael Lincoff, Kai Wang

Arteriosclerosis, Thrombosis, and Vascular Biology October 2002, 22 (10) 1598-1603; DOI: https://doi.org/10.1161/01.ATV.0000032676.20514.8F

Figure 2. Photomicrographs of representative CD45 immunostaining showing arteries from cont...
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Figure 2. Photomicrographs of representative CD45 immunostaining showing arteries from control and rPSGL–treated rats at 1, 3, and 7 days after balloon injury. A, Section from control rat at day 1 showed intense CD45 immunostaining. B, Section from control rat at day 3 showed CD45 staining around lumen. C, By day 7, control rat sections still had intense CD45 staining, observed around lumen and extending into media. D through F, Much less CD45 immunostaining was observed in rPSGL–treated rat at days 1, 3, and 7.
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Administration of Recombinant P-Selectin Glycoprotein Ligand Fc Fusion Protein Suppresses Inflammation and Neointimal Formation in Zucker Diabetic Rat Model
Zhongmin Zhou, Marc S. Penn, Farhad Forudi, Xiaorong Zhou, Khaldoun Tarakji, Eric J. Topol, A. Michael Lincoff, Kai Wang

Arteriosclerosis, Thrombosis, and Vascular Biology October 2002, 22 (10) 1598-1603; DOI: https://doi.org/10.1161/01.ATV.0000032676.20514.8F

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Table 2.
% Area Occupied by CD45 Positive Leukocytes After Balloon Injury
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% Area Occupied by CD45 Positive Leukocytes After Balloon Injury
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Administration of Recombinant P-Selectin Glycoprotein Ligand Fc Fusion Protein Suppresses Inflammation and Neointimal Formation in Zucker Diabetic Rat Model
Zhongmin Zhou, Marc S. Penn, Farhad Forudi, Xiaorong Zhou, Khaldoun Tarakji, Eric J. Topol, A. Michael Lincoff, Kai Wang

Arteriosclerosis, Thrombosis, and Vascular Biology October 2002, 22 (10) 1598-1603; DOI: https://doi.org/10.1161/01.ATV.0000032676.20514.8F

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Table 3.
Morphometric Results
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Morphometric Results
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Administration of Recombinant P-Selectin Glycoprotein Ligand Fc Fusion Protein Suppresses Inflammation and Neointimal Formation in Zucker Diabetic Rat Model
Zhongmin Zhou, Marc S. Penn, Farhad Forudi, Xiaorong Zhou, Khaldoun Tarakji, Eric J. Topol, A. Michael Lincoff, Kai Wang

Arteriosclerosis, Thrombosis, and Vascular Biology October 2002, 22 (10) 1598-1603; DOI: https://doi.org/10.1161/01.ATV.0000032676.20514.8F

Figure 3. Photomicrographs of carotid arteries 21 days after balloon injury (Movat, ×5). A,...
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Figure 3. Photomicrographs of carotid arteries 21 days after balloon injury (Movat, ×5). A, Representative light microscopy of cross section of injured carotid artery from rPSGL treatment group showing reduced neointimal hyperplasia with large luminal area. B, Representative light microscopy of cross section of injured carotid artery from control group showing extensive neointimal hyperplasia with smaller luminal area.
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