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Search for author "A. Michael Lincoff"

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    Antithrombotic Effect of Tissue Factor Inhibition by Inactivated Factor VIIaAn Ex Vivo Human Study
    Eli I. Lev, Jonathan D. Marmur, Milan Zdravkovic, Julio I. Osende, Jonathan Robbins, Jenny A. Delfin, Merwin Richard, Elisabeth Erhardtsen, Mikael S. Thomsen, A. Michael Lincoff and Juan J. Badimon
    Arteriosclerosis, Thrombosis, and Vascular Biology. 2002;22:1036-1041, originally published April 25, 2002
    https://doi.org/10.1161/01.ATV.0000019732.25208.B8
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    Antithrombotic Effect of Tissue Factor Inhibition by Inactivated Factor VIIa
    Eli I. Lev, Jonathan D. Marmur, Milan Zdravkovic, Julio I. Osende, Jonathan Robbins, Jenny A. Delfin, Merwin Richard, Elisabeth Erhardtsen, Mikael S. Thomsen, A. Michael Lincoff, Juan J. Badimon
    Arteriosclerosis, Thrombosis, and Vascular Biology June 2002, 22 (6) 1036-1041; DOI: https://doi.org/10.1161/01.ATV.0000019732.25208.B8
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    Table 1.
    Clinical CharacteristicsShow More
    Clinical CharacteristicsShow Less
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    Antithrombotic Effect of Tissue Factor Inhibition by Inactivated Factor VIIa
    Eli I. Lev, Jonathan D. Marmur, Milan Zdravkovic, Julio I. Osende, Jonathan Robbins, Jenny A. Delfin, Merwin Richard, Elisabeth Erhardtsen, Mikael S. Thomsen, A. Michael Lincoff, Juan J. Badimon
    Arteriosclerosis, Thrombosis, and Vascular Biology June 2002, 22 (6) 1036-1041; DOI: https://doi.org/10.1161/01.ATV.0000019732.25208.B8
    Figure 1. Total thrombus formation in the 3 treatment groups at baseline (black bars) and a...
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    Figure 1. Total thrombus formation in the 3 treatment groups at baseline (black bars) and after drug administration (white bars). Group 1 (n=9) received 400 μg/kg FFR-rFVIIa, group 2 (n=7) received 200 μg/kg FFR-rFVIIa, and group 3 (n=8) received 50 μg/kg FFR-rFVIIa. Results are presented for the 3 types of flow chambers (tunica media without TF coverage, 0.1-mm diameter; tunica media with TF, 0.2-mm diameter; and tunica media with TF, 0.1-mm diameter). Total thrombus results are expressed as mean±SEM (in micrometers squared). *P<0.02, †P<0.01, and ‡P<0.03 for baseline vs after drug administration.
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    Antithrombotic Effect of Tissue Factor Inhibition by Inactivated Factor VIIa
    Eli I. Lev, Jonathan D. Marmur, Milan Zdravkovic, Julio I. Osende, Jonathan Robbins, Jenny A. Delfin, Merwin Richard, Elisabeth Erhardtsen, Mikael S. Thomsen, A. Michael Lincoff, Juan J. Badimon
    Arteriosclerosis, Thrombosis, and Vascular Biology June 2002, 22 (6) 1036-1041; DOI: https://doi.org/10.1161/01.ATV.0000019732.25208.B8
    Figure 2. Representative photomicrographs of porcine media exposed to flowing blood from a...
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    Figure 2. Representative photomicrographs of porcine media exposed to flowing blood from a group 1 patient. Micrograph A was taken at baseline (after heparin bolus); micrograph B was taken after FFR-rFVIIa+heparin administration. Sections were stained with combined Masson’s trichrome-elastin (CME) to demonstrate total thrombus deposition. Original magnification ×100.
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    Antithrombotic Effect of Tissue Factor Inhibition by Inactivated Factor VIIa
    Eli I. Lev, Jonathan D. Marmur, Milan Zdravkovic, Julio I. Osende, Jonathan Robbins, Jenny A. Delfin, Merwin Richard, Elisabeth Erhardtsen, Mikael S. Thomsen, A. Michael Lincoff, Juan J. Badimon
    Arteriosclerosis, Thrombosis, and Vascular Biology June 2002, 22 (6) 1036-1041; DOI: https://doi.org/10.1161/01.ATV.0000019732.25208.B8
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    Table 2.
    Results of Complete Blood Count, Platelet Function and Coagulation TestsShow More
    Results of Complete Blood Count, Platelet Function and Coagulation TestsShow Less
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