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  • Open Access
    Safety and Tolerability of CSL112, a Reconstituted, Infusible, Plasma-Derived Apolipoprotein A-I, After Acute Myocardial InfarctionClinical PerspectiveThe AEGIS-I Trial (ApoA-I Event Reducing in Ischemic Syndromes I)
    C. Michael Gibson, Serge Korjian, Pierluigi Tricoci, Yazan Daaboul, Megan Yee, Purva Jain, John H. Alexander, P. Gabriel Steg, A. Michael Lincoff, John J.P. Kastelein, Roxana Mehran, Denise M. D’Andrea, Lawrence I. Deckelbaum, Bela Merkely, Maciej Zarebinski, Ton Oude Ophuis and Robert A. Harrington
    Circulation. 2016;134:1918-1930, originally published November 15, 2016
    https://doi.org/10.1161/CIRCULATIONAHA.116.025687
  • Open Access
    Safety and Tolerability of CSL112, a Reconstituted, Infusible, Plasma-Derived Apolipoprotein A-I, After Acute Myocardial InfarctionClinical Perspective
    C. Michael Gibson, Serge Korjian, Pierluigi Tricoci, Yazan Daaboul, Megan Yee, Purva Jain, John H. Alexander, P. Gabriel Steg, A. Michael Lincoff, John J.P. Kastelein, Roxana Mehran, Denise M. D’Andrea, Lawrence I. Deckelbaum, Bela Merkely, Maciej Zarebinski, Ton Oude Ophuis, Robert A. Harrington
    Circulation December 2016, 134 (24) 1918-1930; DOI: https://doi.org/10.1161/CIRCULATIONAHA.116.025687
    View table
    Table 1.
    By C. Michael Gibson, Serge Korjian, Pierluigi Tricoci, Yazan Daaboul, Megan Yee, Purva Jain, John H. Alexander, P. Gabriel Steg, A. Michael Lincoff, John J.P. Kastelein, Roxana Mehran, Denise M. D’Andrea, Lawrence I. Deckelbaum, Bela Merkely, Maciej Zarebinski, Ton Oude Ophuis and Robert A. Harrington
    Baseline CharacteristicsShow More
  • Open Access
    Safety and Tolerability of CSL112, a Reconstituted, Infusible, Plasma-Derived Apolipoprotein A-I, After Acute Myocardial InfarctionClinical Perspective
    C. Michael Gibson, Serge Korjian, Pierluigi Tricoci, Yazan Daaboul, Megan Yee, Purva Jain, John H. Alexander, P. Gabriel Steg, A. Michael Lincoff, John J.P. Kastelein, Roxana Mehran, Denise M. D’Andrea, Lawrence I. Deckelbaum, Bela Merkely, Maciej Zarebinski, Ton Oude Ophuis, Robert A. Harrington
    Circulation December 2016, 134 (24) 1918-1930; DOI: https://doi.org/10.1161/CIRCULATIONAHA.116.025687
    Figure 1.
    Figure 1.
    By C. Michael Gibson, Serge Korjian, Pierluigi Tricoci, Yazan Daaboul, Megan Yee, Purva Jain, John H. Alexander, P. Gabriel Steg, A. Michael Lincoff, John J.P. Kastelein, Roxana Mehran, Denise M. D’Andrea, Lawrence I. Deckelbaum, Bela Merkely, Maciej Zarebinski, Ton Oude Ophuis and Robert A. Harrington
    CONSORT (Consolidated Standards of Reporting Trials) diagram. ITT indicates intent to treat...
    Show More
  • Open Access
    Safety and Tolerability of CSL112, a Reconstituted, Infusible, Plasma-Derived Apolipoprotein A-I, After Acute Myocardial InfarctionClinical Perspective
    C. Michael Gibson, Serge Korjian, Pierluigi Tricoci, Yazan Daaboul, Megan Yee, Purva Jain, John H. Alexander, P. Gabriel Steg, A. Michael Lincoff, John J.P. Kastelein, Roxana Mehran, Denise M. D’Andrea, Lawrence I. Deckelbaum, Bela Merkely, Maciej Zarebinski, Ton Oude Ophuis, Robert A. Harrington
    Circulation December 2016, 134 (24) 1918-1930; DOI: https://doi.org/10.1161/CIRCULATIONAHA.116.025687
    View table
    Table 2.
    By C. Michael Gibson, Serge Korjian, Pierluigi Tricoci, Yazan Daaboul, Megan Yee, Purva Jain, John H. Alexander, P. Gabriel Steg, A. Michael Lincoff, John J.P. Kastelein, Roxana Mehran, Denise M. D’Andrea, Lawrence I. Deckelbaum, Bela Merkely, Maciej Zarebinski, Ton Oude Ophuis and Robert A. Harrington
    Coprimary Safety End PointsShow More
  • Open Access
    Safety and Tolerability of CSL112, a Reconstituted, Infusible, Plasma-Derived Apolipoprotein A-I, After Acute Myocardial InfarctionClinical Perspective
    C. Michael Gibson, Serge Korjian, Pierluigi Tricoci, Yazan Daaboul, Megan Yee, Purva Jain, John H. Alexander, P. Gabriel Steg, A. Michael Lincoff, John J.P. Kastelein, Roxana Mehran, Denise M. D’Andrea, Lawrence I. Deckelbaum, Bela Merkely, Maciej Zarebinski, Ton Oude Ophuis, Robert A. Harrington
    Circulation December 2016, 134 (24) 1918-1930; DOI: https://doi.org/10.1161/CIRCULATIONAHA.116.025687
    View table
    Table 3.
    By C. Michael Gibson, Serge Korjian, Pierluigi Tricoci, Yazan Daaboul, Megan Yee, Purva Jain, John H. Alexander, P. Gabriel Steg, A. Michael Lincoff, John J.P. Kastelein, Roxana Mehran, Denise M. D’Andrea, Lawrence I. Deckelbaum, Bela Merkely, Maciej Zarebinski, Ton Oude Ophuis and Robert A. Harrington
    MACE End Points in the Intent-to-Treat PopulationShow More
  • Open Access
    Safety and Tolerability of CSL112, a Reconstituted, Infusible, Plasma-Derived Apolipoprotein A-I, After Acute Myocardial InfarctionClinical Perspective
    C. Michael Gibson, Serge Korjian, Pierluigi Tricoci, Yazan Daaboul, Megan Yee, Purva Jain, John H. Alexander, P. Gabriel Steg, A. Michael Lincoff, John J.P. Kastelein, Roxana Mehran, Denise M. D’Andrea, Lawrence I. Deckelbaum, Bela Merkely, Maciej Zarebinski, Ton Oude Ophuis, Robert A. Harrington
    Circulation December 2016, 134 (24) 1918-1930; DOI: https://doi.org/10.1161/CIRCULATIONAHA.116.025687
    Figure 2.
    Figure 2.
    By C. Michael Gibson, Serge Korjian, Pierluigi Tricoci, Yazan Daaboul, Megan Yee, Purva Jain, John H. Alexander, P. Gabriel Steg, A. Michael Lincoff, John J.P. Kastelein, Roxana Mehran, Denise M. D’Andrea, Lawrence I. Deckelbaum, Bela Merkely, Maciej Zarebinski, Ton Oude Ophuis and Robert A. Harrington
    Time to occurrence of first major adverse cardiovascular event (MACE). Composite of cardiov...
    Show More
  • Open Access
    Safety and Tolerability of CSL112, a Reconstituted, Infusible, Plasma-Derived Apolipoprotein A-I, After Acute Myocardial InfarctionClinical Perspective
    C. Michael Gibson, Serge Korjian, Pierluigi Tricoci, Yazan Daaboul, Megan Yee, Purva Jain, John H. Alexander, P. Gabriel Steg, A. Michael Lincoff, John J.P. Kastelein, Roxana Mehran, Denise M. D’Andrea, Lawrence I. Deckelbaum, Bela Merkely, Maciej Zarebinski, Ton Oude Ophuis, Robert A. Harrington
    Circulation December 2016, 134 (24) 1918-1930; DOI: https://doi.org/10.1161/CIRCULATIONAHA.116.025687
    Figure 3.
    Figure 3.
    By C. Michael Gibson, Serge Korjian, Pierluigi Tricoci, Yazan Daaboul, Megan Yee, Purva Jain, John H. Alexander, P. Gabriel Steg, A. Michael Lincoff, John J.P. Kastelein, Roxana Mehran, Denise M. D’Andrea, Lawrence I. Deckelbaum, Bela Merkely, Maciej Zarebinski, Ton Oude Ophuis and Robert A. Harrington
    Time to occurrence of first exploratory major adverse cardiovascular event (MACE). Composit...
    Show More
  • Open Access
    Safety and Tolerability of CSL112, a Reconstituted, Infusible, Plasma-Derived Apolipoprotein A-I, After Acute Myocardial InfarctionClinical Perspective
    C. Michael Gibson, Serge Korjian, Pierluigi Tricoci, Yazan Daaboul, Megan Yee, Purva Jain, John H. Alexander, P. Gabriel Steg, A. Michael Lincoff, John J.P. Kastelein, Roxana Mehran, Denise M. D’Andrea, Lawrence I. Deckelbaum, Bela Merkely, Maciej Zarebinski, Ton Oude Ophuis, Robert A. Harrington
    Circulation December 2016, 134 (24) 1918-1930; DOI: https://doi.org/10.1161/CIRCULATIONAHA.116.025687
    View table
    Table 4.
    By C. Michael Gibson, Serge Korjian, Pierluigi Tricoci, Yazan Daaboul, Megan Yee, Purva Jain, John H. Alexander, P. Gabriel Steg, A. Michael Lincoff, John J.P. Kastelein, Roxana Mehran, Denise M. D’Andrea, Lawrence I. Deckelbaum, Bela Merkely, Maciej Zarebinski, Ton Oude Ophuis and Robert A. Harrington
    Bleeding Academic Research Consortium Evaluation Grades for Worst Bleeding Events: Safety PopulationShow More
  • Open Access
    Safety and Tolerability of CSL112, a Reconstituted, Infusible, Plasma-Derived Apolipoprotein A-I, After Acute Myocardial InfarctionClinical Perspective
    C. Michael Gibson, Serge Korjian, Pierluigi Tricoci, Yazan Daaboul, Megan Yee, Purva Jain, John H. Alexander, P. Gabriel Steg, A. Michael Lincoff, John J.P. Kastelein, Roxana Mehran, Denise M. D’Andrea, Lawrence I. Deckelbaum, Bela Merkely, Maciej Zarebinski, Ton Oude Ophuis, Robert A. Harrington
    Circulation December 2016, 134 (24) 1918-1930; DOI: https://doi.org/10.1161/CIRCULATIONAHA.116.025687
    View table
    Table 5.
    By C. Michael Gibson, Serge Korjian, Pierluigi Tricoci, Yazan Daaboul, Megan Yee, Purva Jain, John H. Alexander, P. Gabriel Steg, A. Michael Lincoff, John J.P. Kastelein, Roxana Mehran, Denise M. D’Andrea, Lawrence I. Deckelbaum, Bela Merkely, Maciej Zarebinski, Ton Oude Ophuis and Robert A. Harrington
    Baseline Lipid and Cardiovascular BiomarkersShow More
  • Open Access
    Safety and Tolerability of CSL112, a Reconstituted, Infusible, Plasma-Derived Apolipoprotein A-I, After Acute Myocardial InfarctionClinical Perspective
    C. Michael Gibson, Serge Korjian, Pierluigi Tricoci, Yazan Daaboul, Megan Yee, Purva Jain, John H. Alexander, P. Gabriel Steg, A. Michael Lincoff, John J.P. Kastelein, Roxana Mehran, Denise M. D’Andrea, Lawrence I. Deckelbaum, Bela Merkely, Maciej Zarebinski, Ton Oude Ophuis, Robert A. Harrington
    Circulation December 2016, 134 (24) 1918-1930; DOI: https://doi.org/10.1161/CIRCULATIONAHA.116.025687
    View table
    Table 6.
    By C. Michael Gibson, Serge Korjian, Pierluigi Tricoci, Yazan Daaboul, Megan Yee, Purva Jain, John H. Alexander, P. Gabriel Steg, A. Michael Lincoff, John J.P. Kastelein, Roxana Mehran, Denise M. D’Andrea, Lawrence I. Deckelbaum, Bela Merkely, Maciej Zarebinski, Ton Oude Ophuis and Robert A. Harrington
    Cholesterol Efflux, HDL Cholesterol, and ApoA-I Values Immediately After Infusion of CSL112Show More

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