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  Platelet, Not Endothelial, P-Selectin Is Required for Neointimal Formation After Vascular Injury

  Kai Wang, Xiaorong Zhou, Zhongmin Zhou, Niladri Mal, Liming Fan, Ming Zhang, A. Michael Lincoff, Edward F. Plow, Eric J. Topol and Marc S. Penn

  Arteriosclerosis, Thrombosis, and Vascular Biology. 2005;25:1584-1589, originally published July 29, 2005

  https://doi.org/10.1161/01.ATV.0000172687.01179.d4

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  Platelet, Not Endothelial, P-Selectin Is Required for Neointimal Formation After Vascular Injury

  Kai Wang, Xiaorong Zhou, Zhongmin Zhou, Niladri Mal, Liming Fan, Ming Zhang, A. Michael Lincoff, Edward F. Plow, Eric J. Topol, Marc S. Penn

  Arteriosclerosis, Thrombosis, and Vascular Biology August 2005, 25 (8) 1584-1589; DOI: https://doi.org/10.1161/01.ATV.0000172687.01179.d4

  

  Figure 1. Flow cytometry results. Activation of platelets from P-selectin−/− mice receiving bone marrow from C57BL/6J had a P-selectin expression simi...Show More

  Figure 1. Flow cytometry results. Activation of platelets from P-selectin−/− mice receiving bone marrow from C57BL/6J had a P-selectin expression similar to that in WT mice, indicating that the bone marrow of P-selectin−/− mice was successfully reconstituted. No P-selectin expression was found in P-selectin−/− mice Activation of platelets from C57BL/6J mice receiving bone marrow from P-selectin−/− mice had a P-selectin expression similar to that in P-selectin−/− mice, indicating that the bone marrow of C57BL/6J mice was successfully reconstituted. Light scatterblot indicates the nonstimulated platelet histogram. Abbreviations are as defined in text.Show Less
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  Platelet, Not Endothelial, P-Selectin Is Required for Neointimal Formation After Vascular Injury

  Kai Wang, Xiaorong Zhou, Zhongmin Zhou, Niladri Mal, Liming Fan, Ming Zhang, A. Michael Lincoff, Edward F. Plow, Eric J. Topol, Marc S. Penn

  Arteriosclerosis, Thrombosis, and Vascular Biology August 2005, 25 (8) 1584-1589; DOI: https://doi.org/10.1161/01.ATV.0000172687.01179.d4

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  Morphometric Data at 21 DaysShow More

  Morphometric Data at 21 DaysShow Less
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  Platelet, Not Endothelial, P-Selectin Is Required for Neointimal Formation After Vascular Injury

  Kai Wang, Xiaorong Zhou, Zhongmin Zhou, Niladri Mal, Liming Fan, Ming Zhang, A. Michael Lincoff, Edward F. Plow, Eric J. Topol, Marc S. Penn

  Arteriosclerosis, Thrombosis, and Vascular Biology August 2005, 25 (8) 1584-1589; DOI: https://doi.org/10.1161/01.ATV.0000172687.01179.d4

  

  Figure 2. Photomicrographs of mice carotid arteries 21 days after injury (elastic staining, ×20). A, Representative cross section of injured artery fr...Show More

  Figure 2. Photomicrographs of mice carotid arteries 21 days after injury (elastic staining, ×20). A, Representative cross section of injured artery from a WT (group 1) mouse, showing extensive neointimal formation. B, Representative cross section of injured artery from a P-selectin−/− (group 2) mouse, showing significantly reduced neointimal formation. C, Representative cross section of injured artery from a Plt-Psel (group 3) mouse, showing extensive neointimal formation. D, Representative cross section of injured artery from an EC-Psel (group 4) mouse, showing significantly reduced neointimal formation. L indicates lumen; N, neointima; and M, media. Other abbreviations are as defined in text.Show Less
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  Platelet, Not Endothelial, P-Selectin Is Required for Neointimal Formation After Vascular Injury

  Kai Wang, Xiaorong Zhou, Zhongmin Zhou, Niladri Mal, Liming Fan, Ming Zhang, A. Michael Lincoff, Edward F. Plow, Eric J. Topol, Marc S. Penn

  Arteriosclerosis, Thrombosis, and Vascular Biology August 2005, 25 (8) 1584-1589; DOI: https://doi.org/10.1161/01.ATV.0000172687.01179.d4

  

  Figure 3. Representative immunohistochemical photomicrographs of injured carotid arteries for neutrophil infiltration. Significantly less neutrophil i...Show More

  Figure 3. Representative immunohistochemical photomicrographs of injured carotid arteries for neutrophil infiltration. Significantly less neutrophil infiltration was observed in the EC-Psel group when compared with the Plt-Psel group at days 4 and 21 after injury (×63). Abbreviations are as defined in text.Show Less
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  Platelet, Not Endothelial, P-Selectin Is Required for Neointimal Formation After Vascular Injury

  Kai Wang, Xiaorong Zhou, Zhongmin Zhou, Niladri Mal, Liming Fan, Ming Zhang, A. Michael Lincoff, Edward F. Plow, Eric J. Topol, Marc S. Penn

  Arteriosclerosis, Thrombosis, and Vascular Biology August 2005, 25 (8) 1584-1589; DOI: https://doi.org/10.1161/01.ATV.0000172687.01179.d4

  

  Figure 4. Representative immunohistochemical photomicrographs of injured carotid arteries for monocyte/macrophage infiltration. Significantly less mon...Show More

  Figure 4. Representative immunohistochemical photomicrographs of injured carotid arteries for monocyte/macrophage infiltration. Significantly less monocyte/macrophage infiltration was observed in the EC-Psel group when compared with the Plt-Psel group at days 4 and 21 after injury (×63). L indicates lumen. Other abbreviations are as defined in text.Show Less
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  Platelet, Not Endothelial, P-Selectin Is Required for Neointimal Formation After Vascular Injury

  Kai Wang, Xiaorong Zhou, Zhongmin Zhou, Niladri Mal, Liming Fan, Ming Zhang, A. Michael Lincoff, Edward F. Plow, Eric J. Topol, Marc S. Penn

  Arteriosclerosis, Thrombosis, and Vascular Biology August 2005, 25 (8) 1584-1589; DOI: https://doi.org/10.1161/01.ATV.0000172687.01179.d4

  

  Figure 5. Immunohistochemical photomicrographs of injured carotid arteries for RANTES expression (×100) and MCP-1 expression (×63). A, Representative...Show More

  Figure 5. Immunohistochemical photomicrographs of injured carotid arteries for RANTES expression (×100) and MCP-1 expression (×63). A, Representative cross section of RANTES expression from the Plt-Psel (group 3) group. B, Representative cross section of RANTES expression from the EC-Psel (group 4) group. C, Representative cross section of MCP-1 expression from the Plt-Psel (group 3) group. D, Representative cross section of MCP-1 expression from the EC-Psel (Group 4). Significantly less RANTES and MCP-1 expression was found in the EC-Psel group, indicating that a greater inflammatory response after arterial injury occurred in the Plt-Psel group. L indicates lumen. Other abbreviations are as defined in text.Show Less
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  Platelet, Not Endothelial, P-Selectin Is Required for Neointimal Formation After Vascular Injury

  Kai Wang, Xiaorong Zhou, Zhongmin Zhou, Niladri Mal, Liming Fan, Ming Zhang, A. Michael Lincoff, Edward F. Plow, Eric J. Topol and Marc S. Penn

  Arteriosclerosis, Thrombosis, and Vascular Biology. 2005;25:1584-1589, originally published July 29, 2005

  https://doi.org/10.1161/01.ATV.0000172687.01179.d4

  Download PDF
• You have access

  Platelet, Not Endothelial, P-Selectin Is Required for Neointimal Formation After Vascular Injury

  Kai Wang, Xiaorong Zhou, Zhongmin Zhou, Niladri Mal, Liming Fan, Ming Zhang, A. Michael Lincoff, Edward F. Plow, Eric J. Topol, Marc S. Penn

  Arteriosclerosis, Thrombosis, and Vascular Biology August 2005, 25 (8) 1584-1589; DOI: https://doi.org/10.1161/01.ATV.0000172687.01179.d4

  

  Figure 1. Flow cytometry results. Activation of platelets from P-selectin−/− mice receiving bone marrow from C57BL/6J had a P-selectin expression simi...Show More

  Figure 1. Flow cytometry results. Activation of platelets from P-selectin−/− mice receiving bone marrow from C57BL/6J had a P-selectin expression similar to that in WT mice, indicating that the bone marrow of P-selectin−/− mice was successfully reconstituted. No P-selectin expression was found in P-selectin−/− mice Activation of platelets from C57BL/6J mice receiving bone marrow from P-selectin−/− mice had a P-selectin expression similar to that in P-selectin−/− mice, indicating that the bone marrow of C57BL/6J mice was successfully reconstituted. Light scatterblot indicates the nonstimulated platelet histogram. Abbreviations are as defined in text.Show Less
• You have access

  Platelet, Not Endothelial, P-Selectin Is Required for Neointimal Formation After Vascular Injury

  Kai Wang, Xiaorong Zhou, Zhongmin Zhou, Niladri Mal, Liming Fan, Ming Zhang, A. Michael Lincoff, Edward F. Plow, Eric J. Topol, Marc S. Penn

  Arteriosclerosis, Thrombosis, and Vascular Biology August 2005, 25 (8) 1584-1589; DOI: https://doi.org/10.1161/01.ATV.0000172687.01179.d4

  View table

  Morphometric Data at 21 DaysShow More

  Morphometric Data at 21 DaysShow Less

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