Table 1.

Glycemic Control, Lipid Levels, and Blood Pressure Among Minimal Gainers (n=394) Versus Excess Gainers (n=122) With Treatment in the EDIC/DCCT Cohort

DCCT CloseoutEDIC Year 1EDIC Year 6
Minimal GainersExcess GainersP ValueMinimal GainersExcess GainersP ValueMinimal GainersExcess GainersP Value
Hemoglobin A1c, %7.1 ± 1.17.1 ± 1.40.177.7 ± 1.38.1 ± 1.2<0.0017.9 ± 1.38.2 ± 1.30.008
Insulin dose, u/kg/day0.62 ± 0.200.74 ± 0.22< 0.0010.74 ± 0.250.82 ± 0.330.030.71 ± 0.260.76 ± 0.260.02
Triglyceride, mmol/L0.84 ± 0.521.0 ± 0.47< 0.0010.91 ± 0.651.2 ± 0.79<0.0010.95 ± 0.641.1 ± 0.68<0.001
Cholesterol level, mmol/L
 Total4.6 ± 0.764.9 ± 0.74< 0.0014.8 ± 0.855.1 ± 0.86<0.0014.9 ± 0.885.1 ± 0.900.03
 LDL2.8 ± 0.703.1 ± 0.66< 0.0012.9 ± 0.773.2 ± 0.75<0.0012.9 ± 0.753.1 ± 0.750.01
 HDL1.4 ± 0.341.3 ± 0.310.0051.4 ± 0.391.3 ± 0.330.021.5 ± 0.421.5 ± 0.390.32
 Non-HDL cholesterol, mmol/L3.2 ± 0.773.6 ± 0.75< 0.0013.4 ± 0.893.7 ± 0.87<0.0013.4 ± 0.903.7 ± 0.880.002
 Percent with LDL>2.59 mmol/L, %6280< 0.00166830.00267770.08
Systolic BP, mm Hg115 ± 12119 ± 12< 0.001116 ± 12120 ± 130.02119 ± 13125 ± 13<0.001
Diastolic BP, mm Hg74 ± 8.877 ± 8.4< 0.00175 ± 8.879 ± 8.3<0.00175 ± 8.778 ± 8.5<0.001
 MetS criteria WC, %4466491259
 MetS criteria HDL, %244222361528
 MetS criteria TG, %58814813
 MetS criteria BP, %153318322339
No. of criteria met
 0, %602259265721
 1, %333931343133
 2, %528827934
 3, %7928310
 4, %02< 0.001*04<0.001*02<0.001*
  • Results are mean ± SD. Metabolic syndrome criteria defined using NCEP criteria.7 BP indicates blood pressure; DCCT, Diabetes Control and Complications Trial; EDIC, Epidemiology of Diabetes Interventions and Complications study; HDL, high-density lipoprotein cholesterol; LDL, low-density lipoprotein cholesterol; MetS, metabolic syndrome; TG, triglyceride; and WC, waist circumference.

  • * χ2 test for proportion of subjects who met 0 to 4 MetS criteria.