Table 2.

Relationship Between Myocardial Infarction and Flavonoid Intake (Total and Subclasses in Quintiles) in Participants From the Nurses’ Health Study II

Quintiles of Flavonoid Intake Subclasses
12345P for Trend
Flavonols, mg/d7.811.615.320.533.2
 Cases, n9976836681
 Person-years329 022330 993331 848330 730328 659
 Age-adjusted model1.00.73 (0.54–0.99)0.78 (0.58–1.05)0.60 (0.44–0.81)0.71 (0.53–0.95)0.009
 Model 2*1.00.84 (0.62–1.13)0.93 (0.69–1.25)0.71 (0.52–0.98)0.81 (0.60–1.09)0.10
 Model 31.00.85 (0.63–1.15)0.95 (0.70–1.28)0.71 (0.51–0.99)0.79 (0.58–1.08)0.08
Flavones, mg/d0.61.01.41.92.9
 Cases, n10586706975
 Person-years327 898329 943330 724332 407330 279
 Age-adjusted model1.00.79 (0.60–1.05)0.62 (0.46–0.84)0.59 (0.43–0.79)0.60 (0.45–0.81)0.0001
 Model 2*1.00.95 (0.71–1.26)0.81 (0.59–1.10)0.82 (0.60–1.13)0.92 (0.68–1.26)0.36
 Model 31.00.98 (0.74–1.32)0.86 (0.62–1.17)0.89 (0.64–1.22)1.00 (0.72–1.40)0.75
Flavanones, mg/d6.615.525.540.171.1
 Cases, n10975598973
 Person-years328 444330 702331 126331 375329 605
 Age-adjusted model1.00.69 (0.51–0.93)0.52 (0.38–0.71)0.77 (0.58–1.01)0.60 (0.44–0.80)0.004
 Model 2*1.00.80 (0.59–1.07)0.64 (0.46–0.88)1.01 (0.76–1.34)0.85 (0.63–1.15)0.66
 Model 31.00.82 (0.61–1.11)0.67 (0.48–0.92)1.07 (0.80–1.44)0.91 (0.66–1.26)0.96
Flavan-3-ols, mg/d13.433.378.9206.2610.2
 Cases, n9964817784
 Person-years328 919330 959331 080330 939329 355
 Age-adjusted model1.00.66 (0.48–0.91)0.84 (0.63–1.13)0.79 (0.58–1.06)0.82 (0.61–1.09)0.40
 Model 2*1.00.76 (0.56–1.05)0.94 (0.70–1.26)0.88 (0.65–1.19)0.86 (0.64–1.15)0.53
 Model 31.00.77 (0.56–1.06)0.94 (0.70–1.27)0.87 (0.64–1.18)0.82 (0.61–1.11)0.37
Anthocyanins, mg/d2.55.08.413.525.1
 Cases, n12681667359
 Person-years324 793330 336331 831332 148332 143
 Age-adjusted model1.00.63 (0.47–0.83)0.50 (0.37–0.67)0.54 (0.40–0.72)0.42 (0.31–0.57)<0.0001
 Model 2*1.00.76 (0.57–1.01)0.66 (0.49–0.90)0.77 (0.58–1.04)0.62 (0.45–0.86)0.006
 Model 31.00.80 (0.60–1.07)0.71 (0.52–0.97)0.85 (0.63–1.15)0.68 (0.49–0.96)0.047
Polymers, mg/d65.4110.1160.9256.7578.6
 Cases, n11280695787
 Person-years327 966331 209331 278331 145329 654
 Age-adjusted model1.00.71 (0.53–0.95)0.61 (0.45–0.82)0.49 (0.36–0.68)0.72 (0.54–0.95)0.002
 Model 2*1.00.85 (0.64–1.14)0.77 (0.57–1.04)0.63 (0.45–0.86)0.84 (0.63–1.12)0.06
 Model 31.00.89 (0.66–1.19)0.80 (0.59–1.08)0.64 (0.46–0.89)0.83 (0.62–1.11)0.051
Total flavonoids, mg/d117.4187.1260.7389.9804.7
 Cases, n10982666583
 Person-years328 518331 254330 948330 890329 641
 Age-adjusted model1.00.73 (0.55–0.98)0.58 (0.43–0.79)0.56 (0.41–0.76)0.69 (0.52–0.92)0.002
 Model 2*1.00.91 (0.68–1.22)0.76 (0.56–1.04)0.74 (0.54–1.01)0.84 (0.62–1.12)0.09
 Model 31.00.96 (0.72–1.28)0.80 (0.58–1.09)0.76 (0.55–1.05)0.83 (0.61–1.12)0.09
  • * Model 2 adjusted for age, physical activity, smoking, body mass index, alcohol, energy, menopausal status, postmenopausal hormone use, aspirin use, oral contraceptive use, and family history of myocardial infarction.

  • Model 3 additionally adjusted for cereal fiber, saturated fatty acids, trans fatty acids, polyunsaturated fatty acids, monounsaturated fatty acids, and caffeine.