Table 5.

Associations Between Metabolic Syndrome Criteria Met at the Time of the DCCT Closeout Visit and Markers of Atherosclerosis (n = 1015)

IMT EDIC Year 1IMT EDIC Year 6CAC EDIC Year 8
MetSyn CriteriaCoefficientStandard ErrorP ValueCoefficientStandard ErrorP ValueOdds Ratio95% CIP Value
HDL0.000820.00450.86–0.000610.00610.921.61.1 to 2.40.01
Triglyceride0.000240.00760.980.0210.0100.040.690.36 to 1.30.28
Blood pressure0.0110.00480.020.0270.00064<0.0011.20.82 to 1.90.31
Waist circumference0.0220.0065<0.0010.0300.0089<0.0011.30.75 to 2.40.32
  • Multiple regression analysis used for IMT measurement. Multiple logistic regression used for CAC measurement. Covariates included in each analysis were age, sex, performance site (machine), treatment group assignment, smoking status, and weighted means of hemoglobin A1c, albumin excretion rate, and total and LDL cholesterol levels. CAC indicates coronary artery calcification; DCCT, Diabetes Control and Complications Trial; EDIC, Epidemiology of Diabetes Interventions and Complications study; HDL, high-density lipoprotein; IMT, intima media thickness; and MetSyn, metabolic syndrome criteria as defined using NCEP criteria.