Table 21-1.

Pooled Prevalence of Valvular Heart Disease From CARDIA, ARIC, and CHS Cohorts

Age, y
18–4445–5455–6465–74≥75P Value for TrendFrequency Adjusted to 2000 US Adult Population
Participants, n4351696124038791745209 128 094
Male1959 (45)258 (37)415 (33)1586 (41)826 (47)100 994 367 (48)
Mitral regurgitation (n=449)23 (0.5)1 (0.1)12 (1.0)250 (6.4)163 (9.3)<0.00011.7% (95% CI, 1.5%–1.9%)
Mitral stenosis (n=15)0 (0)1 (0.1)3 (0.2)7 (0.2)4 (0.2)0.0060.1% (95% CI, 0.02%–0.2%)
Aortic regurgitation (n=90)10 (0.2)1 (0.1)8 (0.7)37 (1.0)34 (2.0)<0.00010.5% (95% CI, 0.3%–0.6%)
Aortic stenosis (n=102)1 (0.02)1 (0.1)2 (0.2)50 (1.3)48 (2.8)<0.00010.4% (95% CI, 0.3%–0.5%)
Any valve disease
 Overall (n=615)31 (0.7)3 (0.4)23 (1.9)328 (8.5)230 (13.2)<0.00012.5% (95% CI, 2.2%–2.7%)
 Women (n=356)19 (0.8)1 (0.2)13 (1.6)208 (9.1)115 (12.6)<0.00012.4% (95% CI, 2.1%–2.8%)
 Men (n=259)12 (0.6)2 (0.8)10 (2.4)120 (7.6)115 (14.0)<0.00012.5% (95% CI, 2.1%–2.9%)
  • Values are n (%) unless otherwise indicated. ARIC indicates Atherosclerosis Risk in Communities study; CARDIA, Coronary Artery Risk Development in Young Adults; CHS, Cardiovascular Health Study; CI, confidence interval; and ellipses (…), not applicable.

  • Reprinted from The Lancet, Nkomo et al1 with permission from Elsevier. Copyright © 2006, Elsevier Ltd.