Table 7-2.

Validated SNPs for CAD, the Nearest Gene, and the OR From the CARDIoGRAMplusC4D Consortium

SNPChromosomeGeneEffect Size (OR)Effect Allele Frequency
rs6026331SORT11.120.77
rs174648571MIA31.050.87
rs171140361PPAP2B1.110.91
rs112065101PCSK91.060.84
rs48456251IL6R1.040.47
rs67258872WDR121.120.11
rs5151352APOB1.080.82
rs22526412ZEB2-AC074093.11.040.46
rs15611982VAMP5-VAMP8-GGCX1.050.45
rs65447132ABCG5-ABCG81.060.30
rs98188703MRAS1.070.14
rs76923874GUCY1A31.060.81
rs18784064EDNRA1.060.15
rs2739095SLC22A4-SLC22A51.090.14
rs122053316ANKS1A1.040.81
rs93696406PHACTR11.090.65
rs121902876TCF211.070.59
rs37982206LPA1.280.01
rs109477896KCNK51.060.76
rs42521206PLG1.060.73
rs115569247ZC3HC11.080.65
rs1253989577q221.080.19
rs20239387HDAC91.070.10
rs2648LPL1.050.86
rs29540298TRIB11.040.55
rs13330499CDKN2A, CDKN2B1.230.47
rs5794599ABO1.070.21
rs250508310KIAA14621.060.42
rs50112010CXCL121.070.83
rs1241340910CYP17A1-CNNM2-NT5C21.100.89
rs224683310LIPA1.060.38
rs932624611ZNF259-APOA5-A4-C3-A11.090.10
rs97481911PDGFD1.070.29
rs318450412SH2B31.070.40
rs477314413COL4A1-COL4A21.070.42
rs931942813FLT11.050.32
rs289581114HHIPL11.060.43
rs717374315ADAMTS71.070.58
rs1751484615FURIN-FES1.050.44
rs228172717SMG6-SRR1.050.36
rs1293658717RASD1-SMCR3-PEMT1.060.59
rs1556317UBE2Z-GIP-ATP5G1-SNF81.040.52
rs112260819LDLR1.100.76
rs207565019ApoE-ApoC11.110.14
rs998260121KCNE21.130.13
  • CAD indicates coronary artery disease; CARDIoGRAMplusC4D, Coronary Artery Disease Genome-wide Replication and Meta-analysis (CARDIOGRAM) plus the Coronary Artery Disease (C4D) Genetics Consortium; OR, odds ratio; and SNP, single-nucleotide polymorphism.

  • Data derived from Deloukas et al.19