Table 46135.

Types of Proarrhythmia During Treatment With Various Antiarrhythmic Drugs for Atrial Fibrillation or Atrial Flutter According to the Vaughan Williams Classification

VW indicates the Vaughan Williams classification of antiarrhythmic drugs (95). VF indicates ventricular fibrillation; AF, atrial fibrillation.
A. Ventricular proarrhythmia
•Torsade de pointes (VW type IA and type III drugs)
•Sustained monomorphic ventricular tachycardia (usually VW type IC drugs)
•Sustained polymorphic ventricular tachycardia/VF without long QT (VW types IA, IC, and III drugs)
B. Atrial proarrhythmia
•Provocation of recurrence (probably VW types IA, IC, and III drugs)
•Conversion of AF to flutter usually VW type IC drugs)
•Increase of defibrillation threshold (a potential problem with VW type IC drugs)
C. Abnormalities of conduction or impulse formation
•Acceleration of ventricular rate during AF (VW type IA and type IC drugs)
•Accelerate conduction over accessory pathway (digoxin, intravenous verapamil or diltiazem)
•Sinus node dysfunction and atrioventricular block (almost all drugs)