Table 106135.

Recommendations for Pharmacological Cardioversion of AF Less Than or Equal to 7 Days Duration**

Drug*Route of AdministrationType of RecommendationLevel of EvidenceReferences
*Drugs are listed alphabetically within each category of recommendation and level of evidence.
**The doses of medications used in these studies may not be the same as those recommended by the manufacturers.
Agents with proven efficacy
DofetilideOralIA133, 225–229
FlecainideOral or intravenousIA88–90, 92, 230–235
IbutilideIntravenousIA236–241
PropafenoneOral or intravenousIA90, 93, 94, 230, 233, 235, 242–252
AmiodaroneOral or intravenousIIaA92, 96, 124, 234, 251, 253–260
QuinidineOralIIbB88, 90, 91, 93, 242, 256, 257, 261, 262
Less effective or incompletely studied agents
ProcainamideIntravenousIIbC237, 238, 263
DigoxinOral or intravenousIIIA93, 233, 244, 259, 264–267
SotalolOral or intravenousIIIA239, 261, 262, 266, 268