Table 116135.

Recommendations for Pharmacological Cardioversion of AF More Than 7 Days Duration**

Drug*Route of AdministrationType of RecommendationLevel of EvidenceReferences
*Drugs are listed alphabetically within each category of recommendation and level of evidence.
**The doses of medications used in these studies may not be the same as those recommended in Table 3 or by the manufacturers.
Agents proven effective
DofetilideOralIA133, 225–229
AmiodaroneOral or intravenousIIaA92, 96, 124, 234, 251, 253–260
IbutilideIntravenousIIaA236–241
FlecainideOralIIbB88–90, 92, 230–235
PropafenoneOral or intravenousIIbB90, 93, 94, 230, 233, 235, 242–252
QuinidineOralIIbB88, 90, 91, 93, 242, 256, 257, 261, 262
Less effective or incompletely studied agents
ProcainamideIntravenousIIbC237, 238, 263
SotalolOral or intravenousIIIA239, 261, 262, 266, 268
DigoxinOral or intravenousIIIC93, 233, 244, 259, 264–267