Table 36135.

Typical Doses of Drugs Used to Maintain Sinus Rhythm in Patients With Atrial Fibrillation**

Drug*Daily DosagePotential Adverse Effects
GI indicates gastrointestinal; AV, atrioventricular; and HF, heart failure.
*Drugs are listed alphabetically.
**The drugs and doses given here have been determined by consensus based on published studies.
†A loading dose of 600 mg per day is usually given for one month or 1000 mg per day over 1 week.
‡Dose should be adjusted for renal function and QT-interval response during in-hospital initiation phase.
Amiodarone100–400 mgPhotosensitivity, pulmonary toxicity, polyneuropathy, GI upset, bradycardia, torsade de pointes (rare), hepatic toxicity, thyroid dysfunction
Disopyramide400–750 mgTorsade de pointes, HF, glaucoma, urinary retention, dry mouth
Dofetilide500–1000 mcgTorsade de pointes
Flecainide200–300 mgVentricular tachycardia, congestive HF, enhanced AV nodal conduction (conversion to atrial flutter)
Procainamide1000–4000 mgTorsade de pointes, lupus-like syndrome, GI symptoms
Propafenone450–900 mgVentricular tachycardia, congestive HF, enhanced AV nodal conduction (conversion to atrial flutter)
Quinidine600–1500 mgTorsade de pointes, GI upset, enhanced AV nodal conduction
Sotalol240–320 mgTorsade de pointes, congestive HF, bradycardia, exacerbation of chronic obstructive or bronchospastic lung disease