Table 1113529.

Biodistribution of 111In-Labeled Anti-TNC Fab′ in EAM and Control Rats

TissueTime After Injection
6 h24 h48 h
PE indicates pulmonary effusion (nonexistent in control rats); muscle, hindlimb skeletal muscle.
Values at each time point represent mean±SD of percentage of injected dose per gram tissue weight. Each EAM or control rat received 0.3 mL 111In anti-TNC Fab′ in saline (3 μCi IV).
EAM rats
    Blood0.45 ±0.080.12 ±0.020.05 ±0.01
    PE0.44 ±0.060.29 ±0.040.12 ±0.03
    Heart2.39 ±0.171.06 ±0.130.59 ±0.20
    Lung0.76 ±0.080.48 ±0.060.48 ±0.17
    Liver3.05 ±0.261.70 ±0.331.20 ±0.27
    Kidney20.78 ±1.3818.69 ±3.6319.12 ±4.90
    Spleen6.00 ±0.465.94 ±1.234.49 ±1.13
    Cerebrum0.01 ±0.000.00 ±0.000.00 ±0.00
    Foot pad0.49 ±0.040.58 ±0.270.52 ±0.18
    Muscle0.15 ±0.170.09 ±0.040.05 ±0.01
    Heart/blood5.35 ±0.758.81 ±1.6212.36 ±5.40
    Heart/lung3.17 ±0.382.25 ±0.341.44 ±0.84
    Heart/liver0.79 ±0.070.65 ±0.160.52 ±0.22
Control rats
    Blood0.88 ±0.080.21 ±0.020.08 ±0.00
    Heart0.32 ±0.030.24 ±0.020.17 ±0.01
    Lung0.50 ±0.060.33 ±0.030.24 ±0.00
    Liver4.51 ±0.552.41 ±0.341.67 ±0.10
    Kidney13.34 ±2.3614.75 ±3.3416.78 ±2.89
    Spleen7.30 ±0.579.04 ±0.767.84 ±0.58
    Cerebrum0.02 ±0.000.01 ±0.000.00 ±0.00
    Foot pad0.47 ±0.071.28 ±0.580.50 ±0.06
    Muscle0.05 ±0.040.03 ±0.010.05 ±0.04
    Heart/blood0.36 ±0.001.16 ±0.182.19 ±0.12
    Heart/lung0.64 ±0.030.74 ±0.050.70 ±0.05
    Heart/liver0.07 ±0.000.10 ±0.010.10 ±0.01