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Original Research Article
Open Access

Direct Comparison of Cardiac Myosin-Binding Protein C with Cardiac Troponins for the Early Diagnosis of Acute Myocardial Infarction

Thomas E. Kaier, Raphael Twerenbold, Christian Puelacher, Jack Marjot, Nazia Imambaccus, Jasper Boeddinghaus, Thomas Nestelberger, Patrick Badertscher, Zaid Sabti, Maria Rubini Giménez, Karin Wildi, Petra Hillinger, Karin Grimm, Sarah Loeffel, Samyut Shrestha, Dayana Flores Widmer, Janosch Cupa, Nikola Kozhuharov, Òscar Miró, F. Javier Martín-Sánchez, Beata Morawiec, Katharina Rentsch, Jens Lohrmann, Wanda Kloos, Stefan Osswald, Tobias Reichlin, Ekkehard Weber, Michael Marber, Christian Mueller
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https://doi.org/10.1161/CIRCULATIONAHA.117.028084
Circulation. 2017;CIRCULATIONAHA.117.028084
Originally published September 26, 2017
Thomas E. Kaier
King's College London BHF Centre, The Rayne Institute, St Thomas' Hospital, London, UK
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Raphael Twerenbold
Department of Cardiology and Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, Switzerland & Department of General and Interventional Cardiology, University Heart Center Hamburg, Hamburg, Germany
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Christian Puelacher
Department of Cardiology and Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, Switzerland
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Jack Marjot
King's College London BHF Centre, The Rayne Institute, St Thomas' Hospital, London, UK
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Nazia Imambaccus
King's College London BHF Centre, The Rayne Institute, St Thomas' Hospital, London, UK
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Jasper Boeddinghaus
Department of Cardiology and Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, Switzerland
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Thomas Nestelberger
Department of Cardiology and Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, Switzerland
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Patrick Badertscher
Department of Cardiology and Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, Switzerland
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Zaid Sabti
Department of Cardiology and Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, Switzerland
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Maria Rubini Giménez
Department of Cardiology and Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, Switzerland & Department of General and Interventional Cardiology, University Heart Center Hamburg, Hamburg, Germany
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Karin Wildi
Department of Cardiology and Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, Switzerland & Emergency Department, CIBERES ISC III, Hospital del Mar - IMIM, Barcelona, Spain
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Petra Hillinger
Department of Cardiology and Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, Switzerland
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Karin Grimm
Department of Cardiology and Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, Switzerland
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Sarah Loeffel
Department of Cardiology and Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, Switzerland
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Samyut Shrestha
Department of Cardiology and Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, Switzerland
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Dayana Flores Widmer
Department of Cardiology and Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, Switzerland
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Janosch Cupa
Department of Cardiology and Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, Switzerland
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Nikola Kozhuharov
Department of Cardiology and Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, Switzerland
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Òscar Miró
Emergency Department, Hospital Clinic, Barcelona, Spain & Global Research in Acute Conditions (GREAT) Network
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F. Javier Martín-Sánchez
Global Research in Acute Conditions (GREAT) Network & Emergency Department, Hospital Clinico San Carlos, Madrid, Spain
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Beata Morawiec
Global Research in Acute Conditions (GREAT) Network & 2nd Cardiology Department, Zabrze, University Silesia, Katowice, Poland
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Katharina Rentsch
Laboratory Medicine, University Hospital Basel, Switzerland
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Jens Lohrmann
Department of Cardiology and Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, Switzerland
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Wanda Kloos
Department of Cardiology and Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, Switzerland
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Stefan Osswald
Department of Cardiology and Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, Switzerland
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Tobias Reichlin
Department of Cardiology and Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, Switzerland
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Ekkehard Weber
Institute of Physiological Chemistry, Martin Luther University Halle-Wittenberg, Halle, Germany
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Michael Marber
King's College London BHF Centre, The Rayne Institute, St Thomas' Hospital, London, UK
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  • For correspondence: mike.marber@kcl.ac.uk
Christian Mueller
Department of Cardiology and Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, Switzerland & Global Research in Acute Conditions (GREAT) Network
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Article Information

CIRCULATIONAHA.117.028084
DOI: 
https://doi.org/10.1161/CIRCULATIONAHA.117.028084
PubMed: 
28972002

Published By: 
American Heart Association, Inc.
Print ISSN: 
0009-7322
Online ISSN: 
1524-4539
History: 
  • Received February 25, 2017
  • Revision received July 13, 2017
  • Accepted August 10, 2017
  • Originally published September 26, 2017.

Article Versions

  • You are currently viewing a Previous Version of this article (September 26, 2017).
  • View the most recent version of this article
Copyright & Usage: 
© 2017 Circulation is published on behalf of the American Heart Association, Inc., by Wolters Kluwer. This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited.

Author Information

  1. Thomas E. Kaier1;
  2. Raphael Twerenbold2;
  3. Christian Puelacher3;
  4. Jack Marjot4;
  5. Nazia Imambaccus4;
  6. Jasper Boeddinghaus3;
  7. Thomas Nestelberger3;
  8. Patrick Badertscher3;
  9. Zaid Sabti3;
  10. Maria Rubini Giménez2;
  11. Karin Wildi5;
  12. Petra Hillinger3;
  13. Karin Grimm3;
  14. Sarah Loeffel3;
  15. Samyut Shrestha3;
  16. Dayana Flores Widmer3;
  17. Janosch Cupa3;
  18. Nikola Kozhuharov3;
  19. Òscar Miró6;
  20. F. Javier Martín-Sánchez7;
  21. Beata Morawiec8;
  22. Katharina Rentsch9;
  23. Jens Lohrmann3;
  24. Wanda Kloos3;
  25. Stefan Osswald3;
  26. Tobias Reichlin3;
  27. Ekkehard Weber10;
  28. Michael Marber1*;
  29. Christian Mueller11
  1. 1King's College London BHF Centre, The Rayne Institute, St Thomas' Hospital, London, UK
  2. 2Department of Cardiology and Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, Switzerland & Department of General and Interventional Cardiology, University Heart Center Hamburg, Hamburg, Germany
  3. 3Department of Cardiology and Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, Switzerland
  4. 4King's College London BHF Centre, The Rayne Institute, St Thomas' Hospital, London, UK
  5. 5Department of Cardiology and Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, Switzerland & Emergency Department, CIBERES ISC III, Hospital del Mar - IMIM, Barcelona, Spain
  6. 6Emergency Department, Hospital Clinic, Barcelona, Spain & Global Research in Acute Conditions (GREAT) Network
  7. 7Global Research in Acute Conditions (GREAT) Network & Emergency Department, Hospital Clinico San Carlos, Madrid, Spain
  8. 8Global Research in Acute Conditions (GREAT) Network & 2nd Cardiology Department, Zabrze, University Silesia, Katowice, Poland
  9. 9Laboratory Medicine, University Hospital Basel, Switzerland
  10. 10Institute of Physiological Chemistry, Martin Luther University Halle-Wittenberg, Halle, Germany
  11. 11Department of Cardiology and Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, Switzerland & Global Research in Acute Conditions (GREAT) Network
  1. ↵* The Rayne Institute, 4th Floor Lambeth Wing, St Thomas' Hospital, Westminster Bridge Road, London SE1 7EH, UK mike.marber{at}kcl.ac.uk


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Sep 2017272701490
Oct 2017235517451341
Nov 2017503538409
Dec 2017239202171
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    Direct Comparison of Cardiac Myosin-Binding Protein C with Cardiac Troponins for the Early Diagnosis of Acute Myocardial Infarction
    Thomas E. Kaier, Raphael Twerenbold, Christian Puelacher, Jack Marjot, Nazia Imambaccus, Jasper Boeddinghaus, Thomas Nestelberger, Patrick Badertscher, Zaid Sabti, Maria Rubini Giménez, Karin Wildi, Petra Hillinger, Karin Grimm, Sarah Loeffel, Samyut Shrestha, Dayana Flores Widmer, Janosch Cupa, Nikola Kozhuharov, Òscar Miró, F. Javier Martín-Sánchez, Beata Morawiec, Katharina Rentsch, Jens Lohrmann, Wanda Kloos, Stefan Osswald, Tobias Reichlin, Ekkehard Weber, Michael Marber and Christian Mueller
    Circulation. 2017;CIRCULATIONAHA.117.028084, originally published September 26, 2017
    https://doi.org/10.1161/CIRCULATIONAHA.117.028084

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    Direct Comparison of Cardiac Myosin-Binding Protein C with Cardiac Troponins for the Early Diagnosis of Acute Myocardial Infarction
    Thomas E. Kaier, Raphael Twerenbold, Christian Puelacher, Jack Marjot, Nazia Imambaccus, Jasper Boeddinghaus, Thomas Nestelberger, Patrick Badertscher, Zaid Sabti, Maria Rubini Giménez, Karin Wildi, Petra Hillinger, Karin Grimm, Sarah Loeffel, Samyut Shrestha, Dayana Flores Widmer, Janosch Cupa, Nikola Kozhuharov, Òscar Miró, F. Javier Martín-Sánchez, Beata Morawiec, Katharina Rentsch, Jens Lohrmann, Wanda Kloos, Stefan Osswald, Tobias Reichlin, Ekkehard Weber, Michael Marber and Christian Mueller
    Circulation. 2017;CIRCULATIONAHA.117.028084, originally published September 26, 2017
    https://doi.org/10.1161/CIRCULATIONAHA.117.028084
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