Should Patients With Cardiovascular Risk Factors Receive Intensive Treatment of Hypertension to <120/80 mmHg Target?: An Antagonist View from HOPE-3
Epidemiological studies show a graded increase in risk at systolic blood pressure (BP) above 115 mmHg and diastolic BP above 75 mmHg. However, it remains unclear if pharmacological BP lowering to these levels reduces CV events and is safe.
Observational analyses raised concerns about aggressive BP lowering to levels below 120/80 mmHg, suggesting the existence of a J-curve phenomenon with increased risk especially for coronary events. However, such analyses are potentially confounded. More reliable data is provided by randomized trials.
- Received August 8, 2016.
- Accepted September 9, 2016.