Changing Cholesterol Levels and Coronary Heart Disease Risk
A report by Colantonio and colleagues in this issue of Circulation describes the relations between serum lipoprotein cholesterol levels and triglycerides with coronary heart disease (CHD) incidence.1 Their analyses draw upon the experience of three American population samples of adults with 8.9 years of follow up. The first study group is the Reasons for Geographic and Racial Differences in Stroke (REGARDS, National Institutes of Health observational cohort, baseline 2003-2007), the second investigation is the Atherosclerosis Risk in Communities (ARIC, National Heart, Lung and Blood observational cohort, baseline 1987-1989), and the third study group is Kaiser Permanente Southern California insured patients (KPSC, persons from a specific geographic region, baseline 2003-2007). The authors conclude that the relation between atherosclerotic lipid levels and first CHD events (definite myocardial infarction, probable myocardial infarction, or coronary death) has diminished when the baseline periods 1988-1997 and 2005-2014 are compared. They also conclude that statin use is largely responsible for a diminution in the risk gradient between lipoprotein cholesterols, especially LDL-C and non-HDL cholesterol (non HDL-C), and CHD events.
- Received December 2, 2015.
- Accepted December 4, 2015.