Applying a Big Data Approach to Biomarker Discovery: Running Before We Walk?
Circulating biomarkers play an increasingly important role in cardiovascular medicine. Clinicians routinely measure biomarkers of cardiac injury, neurohormonal activation, and renal function for diagnosis and risk assessment, and to guide therapeutic decision-making. Several intersecting trends have heightened interest in discovery and validation of additional cardiovascular biomarkers, including the highly anticipated transition to personalized or precision medicine, as well as the pending availability of "big data" sets that promise a dizzying array of patient-level data, including unprecedented numbers of biomarkers.
- Received October 21, 2015.
- Accepted October 23, 2015.