Procoagulant Platelets: Not Just Full of Hot Air
Abnormalities in coagulation are a leading cause of disease and death worldwide due to thrombotic events such as myocardial infarction, stroke, etc. It has been estimated that the cost of treatment of these disorders will rise to over 820 billion by the year 2030.1 At the center of thrombus formation is the platelet, a cell that is seen as the cornerstone of hemostasis and thrombosis. Platelets mainly function to secure hemostasis by acting as the "band-aids of the blood". They are the first responders to sites of vascular injury, bringing with them a membrane surface that provides the "glue" for clot formation as well as a number of proteins essential for coagulation. Platelet involvement ultimately leads to thrombin generation and clot stabilization through fibrin formation.
- Received August 27, 2015.
- Accepted August 31, 2015.