Inside Out Signaling: Moving the AT1 Receptor in To Get the Message Out
With cardiovascular disease remaining a major cause of morbidity and mortality in spite of recent therapeutic advances, the molecular basis of heart failure continues to be an active field of investigation. In particular, the renin-angiotensin system (RAS), which plays a major role in blood pressure control and cardiac hypertrophy, has been the subject of countless studies. The RAS comprises a complex set of proteolytic processing steps and interconnected signaling pathways, acting both systemically and locally, and involving multiple angiotensin (Ang) peptides and receptors. Of these, the most extensively studied are AngII, considered to be the major effector molecule of the RAS, and one of its receptors, the AngII type 1 receptor (AT1R).
- Received May 11, 2015.
- Accepted May 13, 2015.