Long Noncoding RNAs as Inducers and Terminators of Vascular Development
Most of the human genome is transcribed1. However only less than 2% of the human genome consists of exonic regions in protein coding genes2. Recent evidence highlights the importance of the non-coding portion of the genome, which previously were believed to be 'junk'. After their landmark discovery as master regulators of gene expression, microRNAs (a class of small non-coding RNAs) received intense attention as investigators explored the possibilities for the development of novel therapeutic approaches for many human diseases including heart failure3. Similarly, long (>200nt) non-coding RNAs (lncRNAs) are increasingly recognized as important modulators of gene expression in several physiological and pathological settings4,5. Recent studies have emphasized the importance of lncRNAs as potential therapeutic targets or biomarkers for heart diseases6,7.
- Received February 18, 2015.
- Revision received March 2, 2015.
- Accepted March 2, 2015.