ADAMTS7 in Cardiovascular Disease: From Bedside to Bench and Back Again?
Metzincins, a family of zinc metalloproteinases able to process all the extracellular matrix (ECM) components, include the matrix metalloprotease (MMP), a disintegrin and metalloproteinase (ADAM), and a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) subfamilies. Metzincins are important regulators of tissue remodeling, particularly vascular remodeling during atherosclerosis development.1 In the atherosclerotic artery wall these enzymes cause profound alterations to the ECM, and these alterations instigate changes in the behavior of endothelial cells (ECs) and vascular smooth muscle cells (VSMCs).2 Recent genome-wide association (GWA) studies have identified ADAMTS7 as a novel locus associated with human coronary atherosclerosis.3, 4 However, a causal link between this secreted zinc metalloprotease and atherosclerosis has yet to be established.
- Received February 17, 2015.
- Accepted February 19, 2015.