Bariatric Surgery: "Roux"-minating on Endothelial Cell and HDL Function
Obesity, defined as a body mass index ≥ 30 kg/m2, is pandemic. Though prevalence in the United States has plateaued at ~31% of adults (78 million), worldwide obesity rates continue to rise1. Perhaps more concerning is the high level of childhood obesity: 16.9% in US and ~13% (and rising) in developing countries2. Why the alarm? Longitudinal studies of overweight or obese individuals have identified a 20 fold increase in risk for developing diabetes mellitus type 2 (T2D) and 1.5 fold increase risk for cardiovascular disease (CVD), including myocardial infarction, stroke and heart failure3, 4. As obesity rates increase, the burden of obesity-associated cardiometabolic diseases on the healthcare system could be overwhelming4. As such, a deeper understanding of the pathophysiology of obesity and new therapeutic strategies to address this pandemic are both urgently needed.
- Received January 30, 2015.
- Accepted February 5, 2015.