Mapping Hyperlipidemia in Young Adulthood to Coronary Risk: Importance of Cumulative Exposure and How to Stay Young
The atherogenic cholesterol content of blood, commonly clinically assessed as low-density lipoprotein cholesterol (LDL-C) or non-high-density lipoprotein cholesterol (non-HDL-C), is the central causal factor in atherosclerosis. Given within-person variability, a one-time assessment of cholesterol tends to underestimate the strength of relationship to coronary heart disease (CHD) risk.1 An etiologically relevant time window for examination of lipids in association with atherosclerotic cardiovascular disease (CVD) risk is multiple decades of life. That is the timeline by which atherosclerosis tends to develop. Therefore, epidemiologic studies with successive lipid assessments and extended time horizons provide especially valuable information.
- Received December 14, 2014.
- Accepted December 15, 2014.