What the Dead Can Teach the Living: The Systemic Nature of Heart Failure with Preserved Ejection Fraction
Heart failure (HF) with preserved ejection fraction (HFpEF) is the most common form of HF. Approximately 90% of new HF cases in older women are HFpEF.1 Adverse outcomes - exercise intolerance, poor quality-of-life, frequent hospitalizations, and reduced survival - approach those of HF with reduced EF (HFrEF). In contrast to HFrEF, the prevalence of HFpEF is increasing and its prognosis is worsening.2 Despite the strong public health importance of HFpEF, its pathogenesis is poorly understood. Our lack of understanding of HFpEF and its treatment is punctuated by the fact that 6 large, well-designed, randomized clinical trials and several smaller ones were all neutral on their primary outcomes. The combination of high prevalence and lack of evidence-based treatments makes HFpEF a high-priority topic for research in cardiovascular disease.
- Heart failure with preserved ejection fraction
- left ventricular hypertrophy
- coronary artery disease
- comorbidities heart failure
- Received December 19, 2014.
- Accepted December 19, 2014.