Is it All Determined at Menarche?
Gender differences in cardiovascular disease (CVD) risk are well-established and have entered risk prediction tools and recommendations for sex-specific interventions.1 Menstrual and reproductive factors may help to understand the female advantage in common cardiovascular lifetime diseases with an obvious protection during the reproductive period. Important developmental and hormonal transitions during a woman's life are menarche and menopause. Menarche occurs late in pubertal development as an indicator of the beginning of the reproductive period.
- Received November 3, 2014.
- Accepted November 6, 2014.