Increased Congenital Heart Defects in Children Born to Women with Systemic Lupus Erythematosus: Results from the Offspring of Systemic Lupus Erythematosus Mothers Registry Study
Background—In a large population-based study, we aimed to determine whether children born to women with systemic lupus erythematosus (SLE) have an increased risk of congenital heart defects (CHD) compared to children born to women without SLE.
Methods and Results—The "Offspring of SLE mothers Registry (OSLER)" includes all women who had ≥1 hospitalization for delivery after SLE diagnosis, identified through Quebec's healthcare databases (1989-2009), and a randomly selected control group of women, matched ≥4:1 for age and year of delivery. We identified children born live to SLE mothers and their matched controls, and ascertained CHD based on ≥1 hospitalization or physician visit with relevant diagnostic codes, within the first 12 months of life. We performed multivariable logistic regression analyses, using the generalized estimating equation method, to adjust for relevant covariates. Five hundred and nine women with SLE had 719 children, while 5824 matched controls had 8493 children. Compared to controls, children born to women with SLE experienced more CHD [5.2% (95%CI 3.7-7.1) versus 1.9% (95%CI 1.6-2.2), difference 3.3% (95%CI 1.9-5.2)]. In multivariable analyses, children born to women with SLE had a substantially increased risk of CHD (OR 2.62, 95%CI 1.77-3.88) compared to controls. In addition, compared to controls, offspring of SLE mothers had a substantially increased risk of having a CHD repair procedure (OR 5.82, 95%CI 1.77-19.09).
Conclusions—Compared to children from the general population, children born to women with SLE have an increased risk of CHD, as well as an increased risk of having a CHD repair procedure.
- Received March 20, 2014.
- Revision received October 7, 2014.
- Accepted October 17, 2014.