Clinical Profile and Influences on Outcomes in Patients Hospitalized for Acute Pericarditis
Background—The clinical profile with regard to gender and the influences on outcomes in patients who have been hospitalized for acute pericarditis are largely uncharacterized.
Methods and Results—We studied all patients aged ≥ 16 years admitted to hospital due to acute pericarditis (post-pericardiotomy and myocardial infarction associated pericarditis were excluded). Data were collected from a Finnish national registry including data on all cardiovascular admissions (670,409) during 9.5 years in 29 hospitals nationwide. During the study period there were 1,361 admissions for acute pericarditis. Pericarditis patients were more likely to be male (64.9% of patients) than female (35.1%) with age-adjusted likelihood ratio of 1.85 (95% confidence interval (CI) 1.65-2.06, p<0.0001) for male sex. Standardized incidence rate of hospitalizations for acute pericarditis was 3.32 per 100.000 person-years. Men aged 16-65 were at higher risk for pericarditis (relative risk (RR) 2.02; CI 1.81-2.26; p<0.0001) than women in general admitted population with highest risk-difference among young adults. Acute pericarditis caused 0.20% (CI 0.19-0.22%) of all cardiovascular admissions. Proportion of caused admissions declined by estimated 51% per 10-year increase in age. In-hospital mortality rate for acute pericarditis was 1.1% (CI 0.6-1.8%). Mortality increased with age (HR 3.26; CI 1.78-5.95; per 10-year increase in age; p=0.0001) and severe co-infection (pneumonia or septicemia) (HR 13.46; CI 2.26-80.01; p<0.005) but was not associated with sex in multivariate analysis.
Conclusions—Patients hospitalized for acute pericarditis are more commonly men. Increasing age and severe co-infection are associated with greater in-hospital mortality in hospitalized acute pericarditis patients.
- Received April 18, 2014.
- Revision received July 29, 2014.
- Accepted August 29, 2014.