Patient-Centered Outcomes Composites? A Glimpse of the Future
The field of medicine is rushing headlong into a new, information-intensive era of practice and research. As medicine learns to wield the tools of "big data," there is growing confidence that physicians and researchers will be able to obtain, measure, and analyze information from multiple sources—including the directly solicited views and preferences of patients.
In this week's issue of Circulation, Stolker and colleagues provide insight into where this major trend may be headed.1 Using a simple questionnaire administered to cardiovascular clinic patients, they uncovered several intriguing findings. First, they noted a difference between clinical trialists and patients regarding the importance ascribed by each group to preventing different specific outcomes that comprise the classical major adverse cardiovascular event (MACE) endpoints used to assess the safety and efficacy of cardiovascular therapies. Second, they found that among the patient respondents to their survey, these weightings also varied as a function of demographic factors. On the basis of these findings, Stolker and colleagues propose that weighted composites could be used to personalize evidence assessment to inform healthcare delivery based on these differences.
- Received September 4, 2014.
- Accepted September 4, 2014.