Battle of the Bulge: The Yin and Yang of VEGF in Obesity
"Material force moves and flows in all directions and in all manners. Its two elements unite and give rise to the concrete. Thus the multiplicity of things and human beings is produced. In their ceaseless successions the two elements of yin and yang constitute the great principles of the universe."
Chang Tsai, Philosopher (1020-1078)
Yin and Yang are fundamental concepts of Chinese philosophy; two complementary yet competing forces that together influence nature and the elements. Yin is the darker, more negative side; Yang is the brighter, more positive side. The concept of yin and yang exists throughout medicine,1 and certainly applies to the biology of the vascular endothelial growth factor (VEGF) family.
- Received July 31, 2014.
- Accepted August 7, 2014.