Alcohol Consumption, Specific Alcoholic Beverages, and Abdominal Aortic Aneurysm
Background—Studies investigating the role of alcohol consumption in development of abdominal aortic aneurysm (AAA) are scarce. We aimed to examine associations between total alcohol consumption, and specific alcoholic beverages, with hazard of AAA.
Methods and Results—44 715 men from the Cohort of Swedish Men and 35 569 women from the Swedish Mammography Cohort, aged 46 to 84 years at baseline 1998, constituted study population. Cox proportional hazards models were used to estimate hazard ratios (HR) with 95% confidence intervals (CI) for the associations between alcohol consumption, assessed through a food frequency questionnaire, and AAA, identified by means of linkage to the Swedish Inpatient Register and the Swedish Vascular Registry (Swedvasc). Over the 14-year follow-up until December 2011 (1 019 954 person-years), AAA occurred in 1020 men and 194 women. Compared with a consumption of 1 glass of alcohol/week (12 grams of ethanol), the HR of AAA among men who consumed 10 glasses/week was 0.80 (95% CI, 0.68-0.94). Corresponding HR among women who consumed 5 glasses/week was 0.57 (95% CI, 0.40-0.82). Among participants free from cardiovascular disease, total alcohol consumption did not seem to be associated with hazard of the disease. The most commonly consumed alcoholic beverages - beer among men and wine among women - were inversely associated, whereas no association was observed for liquor.
Conclusions—Moderate alcohol consumption, specifically wine and beer, was associated with a lower hazard of abdominal aortic aneurysm. The associations between higher doses of alcohol and risk of the disease remain unknown.
- Received December 19, 2013.
- Revision received May 26, 2014.
- Accepted June 11, 2014.