The Endothelium: Paracrine Mediator of Aortic Dissection
For over 30 years the endothelium has assumed greater and greater importance in our understanding of the development of vascular pathology. This includes the discoveries that the endothelium releases powerful vasodilator and antiplatelet mediators, prostacyclin and nitric oxide, as well as its role in governing permeability, inflammation, and monocyte/macrophage infiltration of the blood vessel. In this issue of Circulation, Fan and colleagues1 show that boosting endothelial-derived oxidants in the mouse aorta by overexpression of the NADPH oxidase isoform, Nox2, during prolonged angiotensin II-induced hypertension, results in a high incidence of infra-renal aortic dissection.
- Received May 6, 2014.
- Accepted May 7, 2014.