Vascular Risk Factors and Midlife Cognition: Re-thinking the Exposure Window
The connection between cerebrovascular health and cognition has been of empirical interest to scientists for over a century. In 1894, Swiss neurologist, Otto Binswanger, described an association between post-mortem cerebrovascular changes, including atherosclerosis, and cognitive impairment preceding death in middle-age and older adults.1 One-hundred and twenty years later, the field has evolved beyond Binswanger's seminal work to include midlife systemic vascular health factors as potential mechanistic drivers in abnormal cognitive aging, including the most common form of dementia, Alzheimer's disease (AD).2,3
- Received February 26, 2014.
- Accepted March 3, 2014.