Assessment of the Heart Microstructure: From Mouse to Man
Stem cell therapy has undergone a rapid translation from bench research to clinical trials as a promising approach for the regeneration of the injured myocardium1,2. Magnetic resonance imaging (MRI) plays a pivotal role in the assessment of stem cell therapy efficacy and elucidation of the mechanisms behind therapeutic effects3. One important aspect of stem cell therapy, however, remains missing: there are currently no non-invasive methods to evaluate the restoration of myocardial tissue microstructure. A study by Sosnovik et al.4 published in this issue of Circulation fills this gap and demonstrates the feasibility of evaluating the integrity and spatial organization of myofibers after cell therapy.
- Received February 28, 2014.
- Accepted March 7, 2014.