The Global Burden of Ischemic Heart Disease in 1990 and 2010: The Global Burden of Disease 2010 Study

Abstract

Background—Ischemic heart disease (IHD) burden consists of years of life lost from IHD deaths and years of disability lived with three non-fatal IHD sequelae: nonfatal acute myocardial infarction (AMI), angina pectoris, and ischemic heart failure. Our aim was to estimate global and regional burden of IHD in 1990 and 2010.

Methods and Results—Global and regional estimates of AMI incidence and angina and heart failure prevalence by age, sex, and world region in 1990 and 2010 were estimated based on data from a systematic review and nonlinear mixed effects meta-regression methods. Age-standardized AMI incidence and angina prevalence decreased globally between 1990 and 2010; ischemic heart failure prevalence increased slightly. The global burden of IHD increased by 29 million disability-adjusted life years (DALYs; 29% increase) between 1990 and 2010. About 32.4% of the growth in global IHD DALYs between 1990 and 2010 was due to aging of the world population, 22.1% due to population growth, and total DALYs were attenuated by a 25.3% decrease in per capita IHD burden (decreased rate). The number of people living with non-fatal IHD increased more than the number of IHD deaths since 1990, but >90% of IHD DALYs in 2010 were due to IHD deaths.

Conclusions—Globally, age-standardized AMI incidence and angina prevalence have decreased, and ischemic heart failure prevalence has increased since 1990. Despite decreased age-standardized fatal and non-fatal IHD in most regions since 1990, population growth and aging led to a higher global burden of IHD in 2010.