Preventing Cardiovascular Complications of Acute Infection: A Missed Opportunity?
"...This is an experimental verification of this medical concept, relatively new, suggesting that infections merit an important place in the etiology of human atheromatous arteritis..."
-Gilbert A and Lion G, Comptes Rendus Hebdomadairesdes Séances et Mémoires de la Société de Biologie. Published 1889
The connections between infection and cardiovascular disease have been postulated for at least 125 years, when Gilbert and Lion observed that acute infection with the typhoid bacillus resulted in atherosclerotic changes to the rabbit aorta. In the last few decades, much work has investigated the role for chronic viral and atypical bacterial infections in progression of atherosclerosis; however trials of antibiotics as secondary prevention for cardiovascular events have been disappointing.1 More recently, epidemiological studies have demonstrated an association between acute infection and cardiovascular events such as acute myocardial infarction,2 stroke,3 cardiomyopathy4 or atrial fibrillation.5
- Received February 5, 2014.
- Accepted February 6, 2014.