Improving Blood Pressure in Children is Protective Over the Long Term
In this issue of Circulation, Dr. Juhola and colleagues from the International Childhood Cardiovascular Cohort Consortium (i3C) address the effect of changing blood pressure (BP) in children on carotid intima-media thickness (CIMT) in adulthood.1 In 4210 children in 4 cohorts around the globe followed for an average of 23 years, children with elevated BP that resolved by adulthood had lower CIMT compared to children whose high BP persisted into adulthood. While i3C is relatively large for a combined pediatric cohort, the study had marginal power to determine whether the small residual risk of resolved BP elevation compared to never-elevated BP was significant. These results represent decades of foresight and diligent effort in presaging the future of cardiovascular disease (CVD) risk. The findings can be contextualized in three domains: in relation to previous data on the long term consequences of elevated BP in youth, the utility of CIMT in youth, and the role of suboptimal data types in clinical decision making.
- cardiovascular disease prevention
- subclinical atherosclerosis risk factor
- blood pressure
- carotid intima-media thickness
- cohort study
- Received June 11, 2013.
- Accepted June 17, 2013.