A Sticky Story for STAT3 in Platelets
The Signal Transducer and Activator of Transcription 3(STAT3) is a cytoplasmic protein that, upon appropriate signaling, translocates to the nucleus and binds DNA response elements of target genes1. As a result, STAT3 mediates the transcription of key mediators involved in mitogenesis, cell survival, apoptosis, cell cycle regulation, angiogenesis, and metastasis development1, 2. STAT3 also regulates the transcription of several genes in megakaryocytes that are required for the formation of platelets (Figure 1 and Drachman et al3).
- Received December 13, 2012.
- Accepted December 17, 2012.
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