Between a ROCK and a Hard Place: How to Align our Circadian Rhythms?
Many, if not all, aspects of biology are temporally controlled to align our temperaments and behavior with a 24 hour world. Such rhythms are driven by the dynamic interplay of a master molecular clock, housed in the suprachiasmatic nucleus, and peripheral tissue clocks, all conditioned by environmental inputs, most of which we poorly understand1. Expression of roughly 20% of genes in most tissues oscillates in a circadian fashion2 and the tightly regulated transcriptional regulation of the clock is complemented by additional controls - by microRNAs3, post-translational4 and epigenetic modifications5. Further underscoring the importance of this system, the molecular clock is highly conserved, exhibits marked elemental redundancy and is central amongst the networks that link biological networks that are prominent in distinct tissues1.
- Received November 16, 2012.
- Accepted November 19, 2012.
- Copyright © 2012, American Heart Association, Inc. All rights reserved. Unauthorized use prohibited