Nutrient-Wide Association Studies: Another Road to the Same Destination
Apart from the specific findings of this analysis, the authors encourage the use of what they call a nutrient-wide association study (NWAS), analogous to a genome-wide association study (GWAS), to investigate dietary determinants of health outcomes1. Similar to the agnostic approach used in a GWAS, the features of their approach include: the inclusion of all available nutrient exposures; non-incorporation of prior knowledge; adjustment of statistical tests for multiple comparisons; division of the primary dataset into training and test subsets; and the use of a confirmatory dataset. The primary objectives are to analyze all possible nutrient-disease hypotheses and to avoid false positive conclusions.
- Received October 17, 2012.
- Accepted October 19, 2012.
- Copyright © 2012, American Heart Association, Inc. All rights reserved. Unauthorized use prohibited