Beets, Bacteria and Blood Flow: A Lesson of Three B's
Angiogenesis and its regulation is a crucial physiological response to chronic tissue ischemia causing increased microvessel growth along with collateral arteriolar remodeling to restore blood flow to deprived tissues1. Vascular occlusion as seen in coronary and peripheral artery disease (CAD and PAD) often progresses to chronic tissue ischemia without effective vascular remodeling responses2. Thus, therapeutic revascularization has an important role to play in the management of patients with CAD or PAD to facilitate ischemic tissue reperfusion and limit cellular injury and loss3. Unfortunately, successful realization of therapeutic angiogenesis remains elusive despite numerous experimental and clinical studies.
- Received September 12, 2012.
- Accepted September 14, 2012.
- Copyright © 2012, American Heart Association, Inc. All rights reserved. Unauthorized use prohibited