On the Fabric of the Human Body
With the publication of De humani corporis fabrica in 1543, Andreas Vesalius bestowed some of the greatest advancements of anatomic understanding since the time of Galen, correcting major misconceptions, for example the notion that the great vessels originated in the liver. It took nearly 1500 years for this evolution in anatomic thinking to transpire. It is simultaneously humbling and invigorating to note that nearly 500 years later the study of anatomy is just as lively and full of evolutionary change. In this issue of Circulation Anversa and colleagues definitively dispatch the dogma of the heart as a terminally differentiated organ, a concept formulated a mere 40 years earlier, and in so doing completely recalibrate our understanding of cellular homeostasis in the healthy and diseased heart.1
- Received August 28, 2012.
- Accepted August 29, 2012.
- Copyright © 2012, American Heart Association, Inc. All rights reserved. Unauthorized use prohibited